卜鹏程-中国科学院大学-UCAS
[中文]
[English]
招生信息
教育背景
工作经历
指导学生
教授课程
专利与奖励
代表性论文
基本信息
卜鹏程 男 博导 中国科学院生物物理研究所电子邮件： bupc@ibp.ac.cn通信地址： 北京市朝阳区大屯路15号邮政编码：
研究领域
非编码RNA与肿瘤，肿瘤代谢，肿瘤干细胞
招生信息
生物化学与分子生物学、生物信息学、细胞生物学、免疫学
招生专业
071009-细胞生物学071010-生物化学与分子生物学
招生方向
非编码RNA与肿瘤，肿瘤干细胞，肿瘤代谢
教育背景
2004-09--2007-07 中科院生物物理研究所 博士2001-09--2004-07 大连理工大学 硕士1997-09--2001-07 大连工业大学 学士
工作经历
工作简历
2008-2010 美国加州大学伯克利分校， 博士后2010-2015 美国康奈尔大学，研究助理2015-2016 美国杜克大学，资深科学家 2016.09-至今 中科院生物物理研究所，研究员
社会兼职
中国生物物理学会代谢生物学分会理事中国抗癌协会肿瘤代谢委员会委员
指导学生
现指导学生晁珊珊 博士研究生 071009-细胞生物学 曹梅 博士研究生 071009-细胞生物学 张丽雯 博士研究生 071009-细胞生物学 叶高琪 博士研究生 071009-细胞生物学 白芙蓉 硕士研究生 1001J6-再生医学 朱子敬 硕士研究生 071010-生物化学与分子生物学 王智 博士研究生 071009-细胞生物学 乔裕锋 博士研究生 071009-细胞生物学 薛瑞新 硕士研究生 071009-细胞生物学 王鹏 硕士研究生 086000-生物与医药 张萱萱 博士研究生 071009-细胞生物学 张飞 博士研究生 071009-细胞生物学
教授课程
肿瘤研究前沿
专利与奖励
国家创新研究群体， 国家级， 2019中组部“青年****”，国家级， 2017中科院“****”， 院级， 2016北京市科学技术奖一等奖 (7/13)， 省级， 2014
代表性论文
1. Liu H#, Du J#, Chao S, Li S, Cai H, Zhang H, Chen G, Liu P, Bu P*. Fusobacterium nucleatum Promotes Colorectal Cancer Cell to Acquire Stem Cell-Like Features by Manipulating Lipid Droplet-Mediated Numb Degradation. Advanced Science. 2022. e2105222. doi: 10.1002/advs.202105222.2. Zhang L, Zhu Z, Yan H, Wang W, Wu Z, Zhang F, Zhang Q, Shi G, Du J, Cai H, Zhang X, Hsu D, Gao P, Piao HL*; Chen G*; Bu P*; Creatine promotes cancer metastasis through activation of Smad2/3, Cell Metabolism. 2021. 33(6):1111-1123. Highlighted in Cell Metabolism3. Yan H#, Wang Z#, Sun Y, Hu L*, Bu P*. Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling. Advanced Science. 2021. 8(22):e2100914. 4. Wu Z#, Liu J#, Chen G, Du J, Cai H, Chen X, Ye G, Luo Y, Luo Y, Zhang L, Duan H2, Liu Z2, Yang S, Sun H, Cui Y, Sun L, Zhang H, Shi G, Wei T, Liu P, Yan Y*, Feng J*, Bu P*. CD146 is a novel ANGPTL2 receptor that promotes obesity by manipulating lipid metabolism and energy expenditure. Advanced Science. 2021. 8(6):2004032. 5. Wang L#, Wang E#, Prado Balcazar J, Wu Z, Xiang K, Wang Y, Huang Q, Negrete M, Chen KY, Li W, Fu Y, Dohlman A, Mines R, Zhang L, Kobayashi Y, Chen T, Shi G, Shen JP, Kopetz S, Tata PR, Moreno V, Gersbach C, Crawford G, Hsu D, Huang E, Bu P*, Shen X*. Advanced Science. 2021. 8(19):e2004673.6. Wang X#*, Liu C#, Zhang S#, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D*. N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles. Devlopmental Cell. 2021. 8;56(5):702-715.7. Bu P#*, Chen KY#, Xiang K#, Johnson C#, Crown SB, Rakhilin N, Ai Y, Wang L, Xi R, Astapova I, Han Y, Li J, Barth BB, Lu M, Gao Z, Mines R, Zhang L, Herman M, Hsu D, Zhang GF, Shen X*. Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metabolism. 2018. 27(6):1249-1262.Highlighted in Nature Reviews Endocrinology8. Wang L, Wang E, Wang Y, Mines R, Xiang K, Sun Z, Zhou G, Chen KY, Rakhilin N, Chao S, Ye G, Wu Z, Yan H, Shen H, Everitt J, Bu P*, Shen X*. miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis. eLife. 2018. 7. pii: e39479. doi: 10.7554/eLife.39479.9. Chen KY, Srinivasan T, Tung KL, Belmonte JM, Wang L, Murthy PKL, Choi J, Rakhilin N, King S, Varanko AK, Witherspoon M, Nishimura N, Glazier JA, Lipkin SM, Bu P*, Shen X*. A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. Molecular Systems Biology. 2017. 13(4):927.10. Bu P#*, Wang L#, Chen KY, Srinivasan T, Murthy PK, Tung KL, Varanko AK, Chen HJ, Ai Y, King S, Lipkin SM, Shen X*. miR-34a and Numb synergize for asymmetric cell fate determination to control stem cell proliferation. Cell Stem Cell. 2016. 18(2):189-202.Highlighted in Cancer Discovery and AAAS11. Wang L#, Bu P#, Ai Y, Srinivasan T, Chen HJ, Xiang K, Lipkin SM, Shen X*. A large non-coding RNA regulates colon cancer stem cell asymmetric division. eLife. 2016; 10.7554/eLife.14620.12. Chen HJ# Wei Z#, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA*, Shuler ML*. A recellularized human colon model identifies cancer driver genes. Nature Biotechnology. 2016. 34(8):845-51.13. Srinivasan T, Walters J, Bu P, Than EB, Tung KL, Chen KY, Panarelli N, Milsom J, Augenlicht L, Lipkin SM*, Shen X*. Notch signaling regulates asymmetric cell fate of fast- and slow-cycling colon cancer initiating cells. Cancer Research. 2016. 76(11):3411-21.14. Bu P#, Wang L#, Chen KY, Rakhilin N, Sun J, Closa A, Tung KL, King S, Kristine Varanko A, Xu Y, Huan Chen J, Zessin AS, Shealy J, Cummings B, Hsu D, Lipkin SM, Moreno V, Gümü? ZH, Shen X*. miR-1269 Promotes Metastasis through a Positive Feedback Loop with TGF- Nat communications. 2015. 6:6879.15. Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L* IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Naure Cell Biology. 2015. 17(12):1546-55.16. Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu Q, Wun B, Roy S, Shen X, King MR*. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials. 2015. 76:52-65.17. Chen HJ, Sun J, Huang Z, Hou H Jr, Arcilla M, Rakhilin N, Joe DJ, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman R, Zhou XK, Edwards R, Chen J, Chen KY, Bu P, Wang L, Xu Y, Munroe R, Abratte C, Miller AD, Gümü? ZH, Shuler M, Nishimura N, Edelmann W, Shen X*, Lipkin SM*. Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer. Nature Biotechnology. 2015. 33(6):656-60.18. Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, He L*. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes & Develop. 2014. 28: 438-45019. Bu P, Chen KY, Chen JH, Wang L, Walters J, Shin YJ, Goerger JP, Sun J, Witherspoon M, Rakhilin N, Li J, Yang H, Milsom J, Lee S, Zipfel W, Jin MM, Gümüş ZH, Lipkin SM*, Shen X*. A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells. Cell Stem Cell. 2013. 12(5):602-625. Highlighted in Cell Stem Cell 20. Chen HJ, Edwards R, Tucci S, Bu P, Milsom J, Lee S, Edelmann W, Gümüs ZH, Shen X*, Lipkin S*. The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis. Journal of Clinical Investigation. 2012. 122(9):3184-9621. Choi YJ#, Lin CP#, Ho JJ, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks GG, Hannon GJ, He L*. miR-34a miRNAs provide a barrier for somatic cell reprogramming. Nature Cell Biology. 2011. 13(11):1353-60.22. Bu P, Zhuang J, Feng J, Yang D, Shen X, Yan X*. Visualization of CD146 dimerization and its regulation in living cells. BBA-Molecular Cell Research. 2007. 1773(4):513-20.23. Bu P, Gao L, Zhuang J, Feng J, Yang D, Yan X*. Anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis via suppression of NF-kB activation. Molecular Cancer Therapy. 2006. 5(11): 2872-2878邀请综述Zhang L, Bu P*. The Two Sides of Creatine in Cancer. Trends in Cell Biology. 2021. S0962-8924(21)00230-0. doi: 10.1016/j.tcb.2021.11.004.Yan H, Bu P*. Non-coding RNAs in cancer. Essays in Biochemistry. 2021. 5(4):625-639. Yan H, Bu P*. Non-coding RNAs in cancer stem cells. Cancer Letters. 2018. 421:121- 126.
2013 中国科学院大学，网络信息中心.