牛北方-中国科学院大学-UCAS
[中文]
[English]
招生信息
教育背景
工作经历
专利与奖励
出版信息
科研活动
合作情况
指导学生
基本信息
牛北方 男 博导 中国科学院计算机网络信息中心电子邮件： bniu@sccas.cn通信地址： 北京市海淀区东升南路2号院中国科学院信息化大厦邮政编码： 100083
研究领域
长期从事临床肿瘤基因组学、医学生物信息学与高性能计算交叉领域的研究工作。聚焦于肿瘤驱动信号及免疫治疗标志物的发现算法和软件技术研发，开发基因组数据建模和机器学习新模型。基于新一代高通量测序技术，提出了基因组微卫星不稳定（MSI）信号印记及精准探测的新方法，形成了国际上引用率最高的肿瘤样本多层次临床应用场景的MSI算法体系，推动了肿瘤免疫治疗领域基础研究的发展。基于蛋白质结构生物学理论，发展了肿瘤驱动突变预测的空间聚类计算方法，发现了药物与癌突变间的多维相互关系及具有前景的泛癌种可成药靶点。基于启发式算法理论，发展了生物序列去冗余的新型分布式并行优化算法和病原微生物全长基因组序列的聚类算法，形成了国际上具有核心地位的生物序列聚类分析算法与软件工具包。迄今发表同行评审论文70余篇，包括Nature、Nature Genetics等期刊，总被引用17000余次，ESI高被引（1%）论文10余篇，其中多项研究成果被媒体报道。是MSIsensor、MuSiC/MuSiC2、HotSpot3D、CD-HIT系列等流行癌症基因检测软件的主要作者。其中的MSIsensor/MSIsensor2/MSIsensor-ct癌症基因组微卫星不稳定性（MSI）检测系统已作为该领域的核心方法之一，在国际上被多家科研单位、医疗机构和公司广泛使用，并被成功应用于FDA批准的首个基于NGS的癌症多基因检测试剂盒（MSK-IMPACT）。主持国家自然科学基金面上项目、国家重点研发计划课题、中科院信息化专项课题等。目前担任中国运筹学会计算生物学分会理事，中国计算机学会高性能计算专委与生物信息学专委委员等。
招生信息
招生专业
081202-计算机软件与理论1001Z1-精准医学
招生方向
高性能计算，医学生物信息学临床肿瘤基因组学
教育背景
2002-09--2009-02 中国科学院计算机网络信息中心 工学博士1998-09--2002-07 山东农业大学计算机系 工学学士
学历
研究生
学位
博士
工作经历
工作简历
2012-08~2015-01,美国圣路易斯华盛顿大学（WUSTL）, Research Scientist2009-03~2012-07,美国加州大学圣迭戈（UCSD）, 博士后
社会兼职
2019-10-23-今,中国科学院计算技术研究所西部高等研究院, 特聘研究员2018-10-20-今,中国计算机学会高性能计算专业委员会, 会员2018-10-13-今,中国计算机学会生物信息专业委员会, 会员2017-09-30-今,贵州大学特聘教授, 兼职教授2016-11-30-今,中国计算机学会, 会员2015-08-13-今,中国运筹学会计算生物学分会, 理事2015-08-11-今,中国运筹学会, 会员
专利与奖励
奖励信息
（1）&nbspTop 10 Clinical Research Achievement Awards for 2015（2015年美国10大临床研究成就奖）,&nbsp,&nbsp国家级,&nbsp2015
专利成果
[1] 陈义夫, 冯仰德, 牛北方, 刘威尔. 基于国家高性能计算环境的中小企业计算社区系统.&nbspCN:&nbspCN112416565A,&nbsp2021-02-26.[2] 邓笋根, 牛北方. 一种共深度点CDP的确定方法及装置.&nbspCN:&nbspCN110068863A,&nbsp2019-07-30.[3] 陆忠华, 李铄, 孙永泽, 代闯闯, 邓笋根, 牛北方. 一种基于Mesos的分布式超参数优化系统及方法.&nbspCN:&nbspCN110046046A,&nbsp2019-07-23.
出版信息
发表论文
[1] Xi Cheng, Haiming Yu, Jinying Li, Xiaona Han, Erhong Meng, Houqing Zhou, Dongliang Wang, Beifang Niu, Xiaotao Zhang. Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline BRCA2 frameshift mutation: a case report. Cancer Biology & Therapy[J]. 2022, [2] Cheng, Shiyu, Li, Xiaochen, Shan, Guihua, Niu, Beifang, Wang, Yang, Luo, MaoKang. ACMViz: a visual analytics approach to understand DRL-based autonomous control model. Journal of Visualization[J]. 2022, 25(2):&nbsp427-442, http://dx.doi.org/10.1007/s12650-021-00793-9.[3] Quan Xu, Yueyue Liu, Jifang Hu, Duan, Xiaohong, Niuben Song, Jiale Zhou, Jincheng Zhai, Junyan Su, Siyao Liu, Fan Chen, Wei Zheng, Zhongjia Guo, Hexiang Li, Qiming Zhou, Beifang Niu. OncoPubMiner: a platform for mining oncology publications. Briefings in Bioinformatics[J]. 2022, 23(5):&nbsphttps://academic.oup.com/bib/article/23/5/bbac383/6691792?searchresult=1#.[4] Xiaoli Shi, Fa Cui, Xinyin Han, Yilin He, Long Zhao, Na Zhang, Hao Zhang, Haidong Zhu, Zhexin Liu, Bin Ma, Shusong Zheng, Wei Zhang, Jiajia Liu, Xiaoli Fan, Yaoqi Si, Shuiquan Tian, Jianqing Niu, Huilan Wu, Xuemei Liu, Zhuo Chen, Deyuan Meng, Xiaoyan Wang, Liqiang Song, Lijing Sun, Jie Han, Hui Zhao, Jun Ji, Zhiguo Wang, Xiaoyu He, Ruilin Li, Xuebin Chi, Chengzhi Liang, Beifang Niu, Jun Xiao, Junming Li, HongQing Ling. Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204. Molecular Plant[J]. 2022, 15(9):&nbsp1440-1456, http://dx.doi.org/10.1016/j.molp.2022.07.008.[5] Lifeng Yan, Zekun Yin, Hao Zhang, Mingkai Wang, Andre Muller, Robin Kobus, Yanjie Wei, Beifang Niu, Bertil Schmidt, Weiguo Liu. RabbitQCPlus: More Efficient Quality Control for Sequencing Data. International Conference on Bioinformatics and Biomedicine (BIBM)null. 2022, [6] Xie, Xuehua, You, Mengxing, Meng, Erhong, Wang, Shunyou, Niu, Beifang, Huang, Weiming. Complete and durable response to crizotinib in a patient with malignant pleural mesothelioma harboring CD74-ROS1 fusion. Journal of Cancer Research and Clinical Oncology[J]. 2022, 148(9):&nbsp2561-2566, http://dx.doi.org/10.1007/s00432-022-04076-0.[7] 何小雨, 韩鑫胤, 牛北方. 肿瘤突变印记的求解算法比较. 计算机系统应用[J]. 2021, 30(12):&nbsp46-54, [8] Han, Xinyin, Zhang, Shuying, Zhou, Daniel Cui, Wang, Dongliang, He, Xiaoyu, Yuan, Danyang, Li, Ruilin, He, Jiayin, Duan, Xiaohong, Wendl, Michael C, Ding, Li, Niu, Beifang. MSIsensor-ct: microsatellite instability detection using cfDNA sequencing data. Briefings in Bioinformatics[J]. 2021, 22(5):&nbsp[9] He, Xiaoyu, Chen, Shanyu, Li, Ruilin, Han, Xinyin, He, Zhipeng, Yuan, Danyang, Zhang, Shuying, Duan, Xiaohong, Niu, Beifang. Comprehensive fundamental somatic variant calling and quality management strategies for human cancer genomes. Briefings in Bioinformatics[J]. 2021, 22(3):&nbsp[10] 代闯闯, 栾海晶, 杨雪莹, 过晓冰, 陆忠华, 牛北方. 区块链技术研究综述. 计算机科学[J]. 2021, 48(11A):&nbsp500-508, [11] 何小雨, 邓笋根, 栾海晶, 牛北方. 国家高性能计算环境的虚拟数据空间运行支撑技术研究. 大数据[J]. 2021, 7(2):&nbsp158-171, http://lib.cqvip.com/Qikan/Article/Detail?id=7104093237.[12] He, Xiaoyu, Zhang, Yu, Yuan, Danyang, Han, Xinyin, He, Jiayin, Duan, Xiaohong, Liu, Siyao, Wang, Xintong, Niu, Beifang. DIVIS: Integrated and Customizable Pipeline for Cancer Genome Sequencing Analysis and Interpretation. FRONTIERS IN ONCOLOGY[J]. 2021, 11: http://dx.doi.org/10.3389/fonc.2021.672597.[13] Danyang Yuan, Xiaoyu He, Xinyin Han, Chunyan Yang, Fei Liu, Shuying Zhang, Haijing Luan, Ruilin Li, Jiayin He, Duan, Xiaohong, Dongliang Wang, Qiming Zhou, Sujun Gao, Beifang Niu. Comprehensive review and evaluation of computational methods for identifying FLT3-internal tenderm duplication in acute myeloid leukaemia. Briefings in Bioinformatics[J]. 2021, 22(5):&nbsp[14] Yin, Zekun, Zhang, Hao, Liu, Meiyang, Zhang, Wen, Song, Honglei, Lan, Haidong, Wei, Yanjie, Niu, Beifang, Schmidt, Bertil, Liu, Weiguo. RabbitQC: high-speed scalable quality control for sequencing data. BIOINFORMATICS[J]. 2021, 37(4):&nbsp573-574, http://dx.doi.org/10.1093/bioinformatics/btaa719.[15] 秦广军, 肖利民, 张广艳, 牛北方, 陈志广. 面向国家高性能计算环境的虚拟数据空间系统. 大数据[J]. 2021, 7(2):&nbsp101-122, http://lib.cqvip.com/Qikan/Article/Detail?id=7104093234.[16] 张舒莹, 韩鑫胤, 何小雨, 袁丹阳, 栾海晶, 李瑞琳, 何佳茵, 牛北方. 基于机器学习的基因组微卫星状态探测方法综述. 数据与计算发展前沿[J]. 2021, 126-135, https://t.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzA0n_znVSGEh23VTYlquiImaTFULhBrMsbV5ietEVNWu.[17] Cheng, Shiyu, Shen, Hanwei, Shan, Guihua, Niu, Beifang, Bai, Weihua. Visual analysis of meteorological satellite data via model-agnostic meta-learning. JOURNAL OF VISUALIZATION[J]. 2021, 24(2):&nbsp301-315, http://dx.doi.org/10.1007/s12650-020-00704-4.[18] Yakneen, Sergei, Waszak, Sebastian M, Gertz, Michael, Korbel, Jan O, Aminou, Brice, Bartolome, Javier, Boroevich, Keith A, Boyce, Rich, Brooks, Angela N, Buchanan, Alex, Buchhalter, Ivo, Butler, Adam P, Byrne, Niall J, Cafferkey, Andy, Campbell, Peter J, Chen, Zhaohong, Cho, Sunghoon, Choi, Wan, Clapham, Peter, DavisDusenbery, Brandi N, De La Vega, Francisco M, Demeulemeester, Jonas, Dow, Michelle T, Dursi, Lewis Jonathan, Eils, Juergen, Eils, Roland, Ellrott, Kyle, Farcas, Claudiu, Favero, Francesco, Fayzullaev, Nodirjon, Ferretti, Vincent, Flicek, Paul, Fonseca, Nuno A, Gelpi, Josep Ll, Getz, Gad, Gibson, Bob, Grossman, Robert L, Harismendy, Olivier, Heath, Allison P, Heinold, Michael C, Hess, Julian M, Hofmann, Oliver, Hong, Jongwhi H, Hudson, Thomas J, Hutter, Barbara, Hutter, Carolyn M, Huebschmann, Daniel, Imoto, Seiya, Ivkovic, Sinisa, Jeon, SeungHyup, Jiao, Wei, Jung, Jongsun, Kabbe, Rolf, Kahles, Andre, Kerssemakers, Jules N A, Kim, HyungLae, Kim, Hyunghwan, Kim, Jihoon, Kim, Youngwook, Kleinheinz, Kortine, Koscher, Michael, Koures, Antonios, Kovacevic, Milena, Lawerenz, Chris, Leshchiner, Ignaty, Liu, Jia, Livitz, Dimitri, Mihaiescu, George L, Mijalkovic, Sanja, Lazic, Ana Mijalkovic, Miyano, Satoru, Miyoshi, Naoki, NahalBose, Hardeep K, Nakagawa, Hidewaki, Nastic, Mia, Newhouse, Steven J, Nicholson, Jonathan, OConnor, Brian D, Ocana, David, Ohi, Kazuhiro, OhnoMachado, Lucila, Omberg, Larsson, Ouellette, B F Francis, Paramasivam, Nagarajan, Perry, Marc D, Pihl, Todd D, Prinz, Manuel, Puiggros, Montserrat, Radovic, Petar, Raine, Keiran M, Rheinbay, Esther, Rosenberg, Mara, Royo, Romina, Raetsch, Gunnar, Saksena, Gordon, Schlesner, Matthias, Shorser, Solomon, I, Short, Charles, Sofia, Heidi J, Spring, Jonathan, Stein, Lincoln D, Struck, Adam J, Tiao, Grace, Tijanic, Nebojsa, Torrents, David, Van Loo, Peter, Vazquez, Miguel, Vicente, David, Wala, Jeremiah A, Wang, Zhining, Weischenfeldt, Joachim, Werner, Johannes, Williams, Ashley, Woo, Youngchoon, Wright, Adam J, Xiang, Qian, Yang, Liming, Yuen, Denis, Yung, Christina K, Zhang, Junjun, PCAWG Tech Working Grp, PCAWG Consortium. Butler enables rapid cloud-based analysis of thousands of human genomes. NATURE BIOTECHNOLOGY[J]. 2020, 38(3):&nbsp288-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000511288100001.[19] Yulia Rubanova, Ruian Shi, Caitlin F Harrigan, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, PCAWG Evolution and Heterogeneity Working Group, Quaid Morris, PCAWG Consortium. Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nature Communications[J]. 2020, 11(1):&nbsp1-12, http://dx.doi.org/10.1038/s41467-020-14352-7.[20] Marta Paczkowska, Jonathan Barenboim, Nardnisa Sintupisut, Natalie S Fox, Helen Zhu, Diala AbdRabbo, Miles W Mee, Paul C Boutros, PCAWG Drivers and Functional Interpretation Working Group, Jri Reimand, PCAWG Consortium. Integrative pathway enrichment analysis of multivariate omics data. Nature Communications[J]. 2020, 11(1):&nbsp1-16, https://doaj.org/article/0e1be01e74114d78838f12db1d7166ab.[21] Sun, Liping, Yu, Yang, Niu, Beifang, Wang, Deqing. Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System. FRONTIERS IN GENETICS[J]. 2020, 11: https://doaj.org/article/000ba4a58eae4514b82cb45cf060e7c7.[22] Constance H Li, Stephenie D Prokopec, Ren X Sun, Fouad Yousif, Nathaniel Schmitz, PCAWG Tumour Subtypes and Clinical Translation, Paul C Boutros, PCAWG Consortium. Sex differences in oncogenic mutational processes. NATURE COMMUNICATIONS[J]. 2020, 11(1):&nbsphttps://doaj.org/article/675a0b63db164a13bc463d8f773c85d4.[23] Zapatka, Marc, Borozan, Ivan, Brewer, Daniel S, Iskar, Murat, Grundhoff, Adam, Alawi, Malik, Desai, Nikita, Sueltmann, Holger, Moch, Holger, Cooper, Colin S, Eils, Roland, Ferretti, Vincent, Lichter, Peter, PCAWG Pathogens, PCAWG Consortium. The landscape of viral associations in human cancers. NATURE GENETICS[J]. 2020, 52(3):&nbsp320-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076016/.[24] CortesCiriano, Isidro, Lee, Jake JuneKoo, Xi, Ruibin, Jain, Dhawal, Jung, Youngsook L, Yang, Lixing, Gordenin, Dmitry, Klimczak, Leszek J, Zhang, ChengZhong, Pellman, David S, Park, Peter J, Akdemir, Kadir C, Alvarez, Eva G, BaezOrtega, Adrian, Beroukhim, Rameen, Boutros, Paul C, Bowtell, David D L, Brors, Benedikt, Burns, Kathleen H, Campbell, Peter J, Chan, Kin, Chen, Ken, DuesoBarroso, Ana, Dunford, Andrew J, Edwards, Paul A, Estivill, Xavier, Etemadmoghadam, Dariush, Feuerbach, Lars, Fink, J Lynn, FrenkelMorgenstern, Milana, Garsed, Dale W, Gerstein, Mark, Gordenin, Dmitry A, Haan, David, Haber, James E, Hess, Julian M, Hutter, Barbara, Imielinski, Marcin, Jones, David T W, Ju, Young Seok, Kazanov, Marat D, Koh, Youngil, Korbel, Jan O, Kumar, Kiran, Lee, Eunjung Alice, Li, Yilong, Lynch, Andy G, Macintyre, Geoff, Markowetz, Florian, Martincorena, Inigo, MartinezFundichely, Alexander, Miyano, Satoru, Nakagawa, Hidewaki, Navarro, Fabio C P, Ossowski, Stephan, Pearson, John, V, Puiggros, Montserrat, Rippe, Karsten, Roberts, Nicola D, Roberts, Steven A, RodriguezMartin, Bernardo, Schumacher, Steven E, Scully, Ralph, Shackleton, Mark, Sidiropoulos, Nikos, Sieverling, Lina, Stewart, Chip, Torrents, David, Tubio, Jose M C, Villasante, Izar, Waddell, Nicola, Wala, Jeremiah A, Weischenfeldt, Joachim, Yao, Xiaotong, Yoon, SungSoo, Zamora, Jorge, PCAWG Struct Variation Working Grp, PCAWG Consortium. Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. NATURE GENETICS[J]. 2020, 52(3):&nbsp331-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000511282900004.[25] Dai, Chuangchuang, Yang, Xueying, Qiu, Meikang, Guo, Xiaobing, Lu, Zhonghua, Niu, Beifang. Digital Currency Investment Strategy Framework Based on Ranking. ALGORITHMS AND ARCHITECTURES FOR PARALLEL PROCESSING, ICA3PP 2020, PT IIInull. 2020, 12454: 654-662, [26] Calabrese, Claudia, Davidson, Natalie R, Demircioglu, Deniz, Fonseca, Nuno A, He, Yao, Kahles, Andre, KjongVan Lehmann, Liu, Fenglin, Shiraishi, Yuichi, Soulette, Cameron M, Urban, Lara, Greger, Liliana, Li, Siliang, Liu, Dongbing, Perry, Marc D, Xiang, Qian, Zhang, Fan, Zhang, Junjun, Bailey, Peter, Erkek, Serap, Hoadley, Katherine A, Hou, Yong, Huska, Matthew R, Kilpinen, Helena, Korbel, Jan O, Marin, Maximillian G, Markowski, Julia, Nandi, Tannistha, PanHammarstrom, Qiang, Pedamallu, Chandra Sekhar, Siebert, Reiner, Stark, Stefan G, Su, Hong, Tan, Patrick, Waszak, Sebastian M, Yung, Christina, Zhu, Shida, Awadalla, Philip, Creighton, Chad J, Meyerson, Matthew, Ouellette, B F Francis, Wu, Kui, Yang, Huanming, Brazma, Alvis, Brooks, Angela N, Goke, Jonathan, Raetsch, Gunnar, Schwarz, Roland F, Stegle, Oliver, Zhang, Zemin, PCAWG Transcriptome Core Grp, PCAWG Transcriptome Working Grp, PCAWG Consortium. Genomic basis for RNA alterations in cancer. NATURE[J]. 2020, 578(7793):&nbsp129-+, http://dx.doi.org/10.1038/s41586-020-1970-0.[27] Chen, Shanyu, He, Xiaoyu, Li, Ruilin, Duan, Xiaohong, Niu, Beifang. HotSpot3D web server: an integrated resource for mutation analysis in protein 3D structures. BIOINFORMATICS[J]. 2020, 36(12):&nbsp3944-3946, https://www.webofscience.com/wos/woscc/full-record/WOS:000550127500061.[28] Campbell, Peter J, Getz, Gad, Korbel, Jan O, Stuart, Joshua M, Jennings, Jennifer L, Stein, Lincoln D, Perry, Marc D, NahalBose, Hardeep K, Ouellette, B F Francis, Li, Constance H, Rheinbay, Esther, Nielsen, G Petur, Sgroi, Dennis C, Wu, ChinLee, Faquin, William C, Deshpande, Vikram, Boutros, Paul C, Lazar, Alexander J, Hoadley, Katherine A, Louis, David N, Dursi, L Jonathan, Yung, Christina K, Bailey, Matthew H, Saksena, Gordon, Raine, Keiran M, Buchhalter, Ivo, Kleinheinz, Kortine, Schlesner, Matthias, Zhang, Junjun, Wang, Wenyi, Wheeler, David A, Ding, Li, Simpson, Jared T, OConnor, Brian D, Yakneen, Sergei, Ellrott, Kyle, Miyoshi, Naoki, Butler, Adam P, Royo, Romina, Shorser, Solomon, I, Vazquez, Miguel, Rausch, Tobias, Tiao, Grace, Waszak, Sebastian M, RodriguezMartin, Bernardo, Shringarpure, Suyash, Wu, DaiYing, Demidov, German M, Delaneau, Olivier, Hayashi, Shuto, Imoto, Seiya, Habermann, Nina, Segre, Ayellet, V, Garrison, Erik, Cafferkey, Andy, Alvarez, Eva G, Maria HerediaGenestar, Jose, Muyas, Francesc, Drechsel, Oliver, Bruzos, Alicia L, Temes, Javier, Zamora, Jorge, BaezOrtega, Adrian, Kim, HyungLae, Mashl, R Jay, Ye, Kai, DiBiase, Anthony, Huang, Kuanlin, Letunic, Ivica, McLellan, Michael D, Newhouse, Steven J, Shmaya, Tal, Kumar, Sushant, Wedge, David C, Wright, Mark H, Yellapantula, Venkata D, Gerstein, Mark, Khurana, Ekta, MarquesBonet, Tomas, Navarro, Arcadi, Bustamante, Carlos D, Siebert, Reiner, Nakagawa, Hidewaki, Easton, Douglas F, Ossowski, Stephan, Tubio, Jose M C, De La Vega, Francisco M, Estivill, Xavier, Yuen, Denis, Mihaiescu, George L, Omberg, Larsson, Ferretti, Vincent, Sabarinathan, Radhakrishnan, Pich, Oriol, GonzalezPerez, Abel, Weiner, Amaro Taylor, Fittall, Matthew W, Demeulemeester, Jonas, Tarabichi, Maxime, Roberts, Nicola D, Van Loo, Peter, CortesCiriano, Isidro, Urban, Lara, Park, Peter, Bin Zhu, Pitkaenen, Esa, Li, Yilong, Saini, Natalie, Klimczak, Leszek J, Weischenfeldt, Joachim, Sidiropoulos, Nikos, Alexandrov, Ludmil B, Rabionet, Raquel, Escaramis, Georgia, Bosio, Mattia, Holik, Aliaksei Z, Susak, Hana, Prasad, Aparna, Erkek, Serap, Calabrese, Claudia, Raeder, Benjamin, Harrington, Eoghan, Mayes, Simon, Turner, Daniel, Juul, Sissel, Roberts, Steven A, Song, Lei, Koster, Roelof, Mirabello, Lisa, Hua, Xing, Tanskanen, Tomas J, Tojo, Marta, Chen, Jieming, Aaltonen, Lauri A, Ratsch, Gunnar, Schwarz, Roland F, Butte, Atul J, Brazma, Alvis, Chanock, Stephen J, Chatterjee, Nilanjan, Stegle, Oliver, Harismendy, Olivier, Bova, G Steven, Gordenin, Dmitry A, Haan, David, Sieverling, Lina, Feuerbach, Lars, Chalmers, Don, Joly, Yann, Knoppers, Bartha, MolnarGabor, Fruzsina, Phillips, Mark, Thorogood, Adrian, Townend, David, Goldman, Mary, Fonseca, Nuno A, Xiang, Qian, Craft, Brian, PineiroYanez, Elena, Munoz, Alfonso, Petryszak, Robert, Fullgrabe, Anja, AlShahrour, Fatima, Keays, Maria, Haussler, David, Weinstein, John, Huber, Wolfgang, Valencia, Alfonso, Papatheodorou, Irene, Zhu, Jingchun, Fan, Yu, Torrents, David, Bieg, Matthias, Chen, Ken, Chong, Zechen, Cibulskis, Kristian, Eils, Roland, Fulton, Robert S, Gelpi, Josep L, Gonzalez, Santiago, Gut, Ivo G, Hach, Faraz, Heinold, Michael, Hu, Taobo, Huang, Vincent, Hutter, Barbara, Jaeger, Natalie, Jung, Jongsun, Kumar, Yogesh, Lalansingh, Christopher, Leshchiner, Ignaty, Livitz, Dimitri, Ma, Eric Z, Maruvka, Yosef E, Milovanovic, Ana, Nielsen, Morten Muhlig, Paramasivam, Nagarajan, Pedersen, Jakob Skou, Puiggros, Montserrat, Sahinalp, S Cenk, Sarrafi, Iman, Stewart, Chip, Stobbe, Miranda D, Wala, Jeremiah A, Wang, Jiayin, Wendl, Michael, Werner, Johannes, Wu, Zhenggang, Xue, Hong, Yamaguchi, Takafumi N, Yellapantula, Venkata, DavisDusenbery, Brandi N, Grossman, Robert L, Kim, Youngwook, Heinold, Michael C, Hinton, Jonathan, Jones, David R, Menzies, Andrew, Stebbings, Lucy, Hess, Julian M, Rosenberg, Mara, Dunford, Andrew J, Gupta, Manaswi, Imielinski, Marcin, Meyerson, Matthew, Beroukhim, Rameen, Reimand, Juri, Dhingra, Priyanka, Favero, Francesco, Dentro, Stefan, Wintersinger, Jeff, Rudneva, Vasilisa, Park, Ji Wan, Hong, Eun Pyo, Heo, Seong Gu, Kahles, Andre, KjongVan Lehmann, Soulette, Cameron M, Shiraishi, Yuichi, Liu, Fenglin, He, Yao, Demircioglu, Deniz, Davidson, Natalie R, Greger, Liliana, Li, Siliang, Liu, Dongbing, Stark, Stefan G, Zhang, Fan, Amin, Samirkumar B, Bailey, Peter, Chateigner, Aurelien, FrenkelMorgenstern, Milana, Hou, Yong, Huska, Matthew R, Kilpinen, Helena, Lamaze, Fabien C, Li, Chang, Li, Xiaobo, Li, Xinyue, Liu, Xingmin, Marin, Maximillian G, Markowski, Julia, Nandi, Tannistha, Ojesina, Akinyemi, I, PanHammarstrom, Qiang, Park, Peter J, Pedamallu, Chandra Sekhar, Su, Hong, Tan, Patrick, Teh, Bin Tean, Wang, Jian, Xiong, Heng, Ye, Chen, Yung, Christina, Zhang, Xiuqing, Zheng, Liangtao, Zhu, Shida, Awadalla, Philip, Creighton, Chad J, Wu, Kui, Yang, Huanming, Goke, Jonathan, Zhang, Zemin, Brooks, Angela N, Martincorena, Inigo, RubioPerez, Carlota, Juul, Malene, Schumacher, Steven, Shapira, Ofer, Tamborero, David, Mularoni, Loris, Hornshoj, Henrik, DeuPons, Jordi, Muinos, Ferran, Bertl, Johanna, Guo, Qianyun, Bazant, Wojciech, Barrera, Elisabet, AlSedairy, Sultan T, Aretz, Axel, Bell, Cindy, Betancourt, Miguel, Buchholz, Christiane, Calvo, Fabien, Chomienne, Christine, Dunn, Michael, Edmonds, Stuart, Green, Eric, Gupta, Shailja, Hutter, Carolyn M, Jegalian, Karine, Jones, Nic, Lu, Youyong, Nakagama, Hitoshi, Nettekoven, Gerd, Planko, Laura, Scott, David, Shibata, Tatsuhiro, Shimizu, Kiyo, Stratton, Michael R, Yugawa, Takashi, Tortora, Giampaolo, VijayRaghavan, K, Zenklusen, Jean C, Knoppers, Bartha M, Aminou, Brice, Bartolome, Javier, Boroevich, Keith A, Boyce, Rich, Buchanan, Alex, Byrne, Niall J, Chen, Zhaohong, Cho, Sunghoon, Choi, Wan, Clapham, Peter, Dow, Michelle T, Dursi, Lewis Jonathan, Eils, Juergen, Farcas, Claudiu, Fayzullaev, Nodirjon, Flicek, Paul, Heath, Allison P, Hofmann, Oliver, Hong, Jongwhi H, Hudson, Thomas J, Huebschmann, Daniel, Ivkovic, Sinisa, Jeon, SeungHyup, Jiao, Wei, Kabbe, Rolf, Kerssemakers, Jules N A, Kim, Hyunghwan, Kim, Jihoon, Koscher, Michael, Koures, Antonios, Kovacevic, Milena, Lawerenz, Chris, Liu, Jia, Mijalkovic, Sanja, MijalkovicLazic, Ana Mijalkovic, Miyano, Satoru, Nastic, Mia, Nicholson, Jonathan, Ocana, David, Ohi, Kazuhiro, OhnoMachado, Lucila, Pihl, Todd D, Prinz, Manuel, Radovic, Petar, Short, Charles, Sofia, Heidi J, Spring, Jonathan, Struck, Adam J, Tijanic, Nebojsa, Vicente, David, Wang, Zhining, Williams, Ashley, Woo, Youngchoon, Wright, Adam J, Yang, Liming, Hamilton, Mark P, Johnson, Todd A, Kahraman, Abdullah, Kellis, Manolis, Polak, Paz, Sallari, Richard, SinnottArmstrong, Nasa, von Mering, Christian, Beltran, Sergi, Gerhard, Daniela S, Gut, Marta, Trotta, JeanRemi, Whalley, Justin P, Niu, Beifang, Espiritu, Shadrielle M G, Gao, Shengjie, Huang, Yi, Lalansingh, Christopher M, Teague, Jon W, Wendl, Michael C, Abascal, Federico, Bader, Gary D, Bandopadhayay, Pratiti, Barenboim, Jonathan, Brunak, Soren, Fita, Joana Carlevaro, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Choi, Jung Kyoon, Diamanti, Klev, Fink, J Lynn, Frigola, Joan, GambacortiPasserini, Carlo, Garsed, Dale W, Haradhvala, Nicholas J, Harmanci, Arif O, Helmy, Mohamed, Herrmann, Carl, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Isaev, Keren, Izarzugaza, Jose M G, Johnson, Rory, Juul, Randi Istrup, Kim, Jaegil, Kim, Jong K, Komorowski, Jan, Lanzos, Andres, Larsson, Erik, Lee, Donghoon, Li, Shantao, Li, Xiaotong, Lin, Ziao, Liu, Eric Minwei, Lochovsky, Lucas, Lou, Shaoke, Madsen, Tobias, Marchal, Kathleen, Fundichely, Alexander Martinez, McGillivray, Patrick D, Meyerson, William, Paczkowska, Marta, Park, Keunchil, Park, Kiejung, Pons, Tirso, PulidoTamayo, Sergio, Reyes Salazar, Iker, Reyna, Matthew A, Rubin, Mark A, Salichos, Leonidas, Sander, Chris, Schumacher, Steven E, Shackleton, Mark, Shen, Ciyue, Shrestha, Raunak, Shuai, Shimin, Tsunoda, Tatsuhiko, Umer, Husen M, UuskulaReimand, Liis, Verbeke, Lieven P C, Wadelius, Claes, Wadi, Lina, Warrell, Jonathan, Wu, Guanming, Yu, Jun, Zhang, Jing, Zhang, Xuanping, Zhang, Yan, Zhao, Zhongming, Zou, Lihua, Lawrence, Michael S, Raphael, Benjamin J, Bailey, Peter J, Craft, David, Goldman, Mary J, Aburatani, Hiroyuki, Binder, Hans, Dinh, Huy Q, Heath, Simon C, Hoffmann, Steve, Imbusch, Charles David, Kretzmer, Helene, Laird, Peter W, MartinSubero, Jose, I, Nagae, Genta, Shen, Hui, Wang, Qi, Weichenhan, Dieter, Zhou, Wanding, Berman, Benjamin P, Brors, Benedikt, Plass, Christoph, Akdemir, Kadir C, Bowtell, David D L, Burns, Kathleen H, Busanovich, John, Chan, Kin, DuesoBarroso, Ana, Edwards, Paul A, Etemadmoghadam, Dariush, Haber, James E, Jones, David T W, Ju, Young Seok, Kazanov, Marat D, Koh, Youngil, Kumar, Kiran, Lee, Eunjung Alice, Lee, Jake JuneKoo, Lynch, Andy G, Macintyre, Geoff, Markowetz, Florian, Navarro, Fabio C P, Pearson, John, V, Rippe, Karsten, Scully, Ralph, Villasante, Izar, Waddell, Nicola, Yang, Lixing, Yao, Xiaotong, Yoon, SungSoo, Zhang, ChengZhong, Bergstrom, Erik N, Boot, Arnoud, Covington, Kyle, Fujimoto, Akihiro, Huang, Mi Ni, Islam, S M Ashiqul, McPherson, John R, Morganella, Sandro, Mustonen, Ville, Ng, Alvin Wei Tian, Prokopec, Stephenie D, VazquezGarcia, Ignacio, Wu, Yang, Yousif, Fouad, Yu, Willie, Rozen, Steven G, Rudneva, Vasilisa A, Shringarpure, Suyash S, Turner, Daniel J, Xia, Tian, Atwal, Gurnit, Chang, David K, Cooke, Susanna L, Faltas, Bishoy M, Haider, Syed, Kaiser, Vera B, Karlic, Rosa, Kato, Mamoru, Kubler, Kirsten, Margolin, Adam, Martin, Sancha, NikZainal, Serena, Png, Christine, Semple, Colin A, Smith, Jaclyn, Sun, Ren X, Thai, Kevin, Wright, Derek W, Yuan, Ke, Biankin, Andrew, V, Garraway, Levi, Grimmond, Sean M, Adams, David J, Anur, Pavana, Cao, Shaolong, Christie, Elizabeth L, Cmero, Marek, Cun, Yupeng, Dawson, Kevin J, Dentro, Stefan C, Deshwar, Amit G, Donmez, Nilgun, Drews, Ruben M, Gerstung, Moritz, Ha, Gavin, Haase, Kerstin, Jerman, Lara, Ji, Yuan, Jolly, Clemency, Lee, Juhee, LeeSix, Henry, Malikic, Salem, Mitchell, Thomas J, Morris, Quaid D, Oesper, Layla, Peifer, Martin, Peto, Myron, Rosebrock, Daniel, Rubanova, Yulia, Salcedo, Adriana, Sengupta, Subhajit, Shi, Ruian, Shin, Seung Jun, Spiro, Oliver, Vembu, Shankar, Wintersinger, Jeffrey A, Yang, TsunPo, Yu, Kaixian, Zhu, Hongtu, Spellman, Paul T, Weinstein, John N, Chen, Yiwen, Fujita, Masashi, Han, Leng, Hasegawa, Takanori, Komura, Mitsuhiro, Li, Jun, Mizuno, Shinichi, Shimizu, Eigo, Wang, Yumeng, Xu, Yanxun, Yamaguchi, Rui, Yang, Fan, Yang, Yang, Yoon, Christopher J, Yuan, Yuan, Liang, Han, Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Grundhoff, Adam, Iskar, Murat, Su, Xiaoping, Zapatka, Marc, Lichter, Peter, Alsop, Kathryn, Bruxner, Timothy J C, Christ, Angelika N, Cordner, Stephen M, Cowin, Prue A, Drapkin, Ronny, Fereday, Sian, George, Joshy, Hamilton, Anne, Holmes, Oliver, Hung, Jillian A, Kassahn, Karin S, Kazakoff, Stephen H, Kennedy, Catherine J, Leonard, Conrad R, Mileshkin, Linda, Miller, David K, Arnau, Gisela Mir, Mitchell, Chris, Newell, Felicity, Nones, Katia, Patch, AnnMarie, Quinn, Michael C, Taylor, Darrin F, Thorne, Heather, Traficante, Nadia, Vedururu, Ravikiran, Waddell, Nick M, Waring, Paul M, Wood, Scott, Xu, Qinying, DeFazio, Anna, Anderson, Matthew J, Antonello, Davide, Barbour, Andrew P, Bassi, Claudio, Bersani, Samantha, Cataldo, Ivana, Chantrill, Lorraine A, Chiew, YokeEng, Chou, Angela, Cingarlini, Sara, Cloonan, Nicole, Corbo, Vincenzo, Davi, Maria Vittoria, Duthie, Fraser R, Gill, Anthony J, Graham, Janet S, Harliwong, Ivon, Jamieson, Nigel B, Johns, Amber L, Kench, James G, Landoni, Luca, Lawlor, Rita T, Mafficini, Andrea, Merrett, Neil D, Miotto, Marco, Musgrove, Elizabeth A, Nagrial, Adnan M, Oien, Karin A, Pajic, Marina, Pinese, Mark, Robertson, Alan J, Rooman, Ilse, Rusev, Borislav C, Samra, Jaswinder S, Scardoni, Maria, Scarlett, Christopher J, Scarpa, Aldo, Sereni, Elisabetta, Sikora, Katarzyna O, Simbolo, Michele, Taschuk, Morgan L, Toon, Christopher W, Vicentini, Caterina, Wu, Jianmin, Zeps, Nikolajs, Behren, Andreas, Burke, Hazel, Cebon, Jonathan, Dagg, Rebecca A, De PaoliIseppi, Ricardo, DuttonRegester, Ken, Field, Matthew A, Fitzgerald, Anna, Hersey, Peter, Jakrot, Valerie, Johansson, Peter A, Kakavand, Hojabr, Kefford, Richard F, Lau, Loretta M S, Long, Georgina, V, Pickett, Hilda A, Pritchard, Antonia L, Pupo, Gulietta M, Saw, Robyn P M, Schramm, SarahJane, Shang, Catherine A, Shang, Ping, Spillane, Andrew J, Stretch, Jonathan R, Tembe, Varsha, Thompson, John F, Vilain, Ricardo E, Wilmott, James S, Yang, Jean Y, Hayward, Nicholas K, Mann, Graham J, Scolyer, Richard A, Bartlett, John, Bavi, Prashant, Chadwick, Dianne E, ChanSengYue, Michelle, Cleary, Sean, Connor, Ashton A, Czajka, Karolina, Denroche, Robert E, Dhani, Neesha C, Eagles, Jenna, Gallinger, Steven, Grant, Robert C, Hedley, David, Hollingsworth, Michael A, Jang, Gun Ho, Johns, Jeremy, Kalimuthu, Sangeetha, Liang, ShengBen, Lungu, Ilinca, Luo, Xuemei, Mbabaali, Faridah, McPherson, Treasa A, Miller, Jessica K, Moore, Malcolm J, Notta, Faiyaz, Pasternack, Danielle, Petersen, Gloria M, Roehrl, Michael H A, Sam, Michelle, Selander, Iris, Serra, Stefano, Shahabi, Sagedeh, Thayer, Sarah P, Timms, Lee E, Wilson, Gavin W, Wilson, Julie M, Wouters, Bradly G, McPherson, John D, Beck, Timothy A, Bhandari, Vinayak, Collins, Colin C, Fleshner, Neil E, Fox, Natalie S, Fraser, Michael, Heisler, Lawrence E, Lalonde, Emilie, Livingstone, Julie, Meng, Alice, Sabelnykova, Veronica Y, Shiah, YuJia, Van Der Kwast, Theodorus, Bristow, Robert G, Ding, Shuai, Fan, Daiming, Li, Lin, Nie, Yongzhan, Xiao, Xiao, Xing, Rui, Yang, Shanlin, Yu, Yingyan, Zhou, Yong, Banks, Rosamonde E, Bourque, Guillaume, Brennan, Paul, Letourneau, Louis, Riazalhosseini, Yasser, Scelo, Ghislaine, Vasudev, Naveen, Viksna, Juris, Lathrop, Mark, Tost, Jorg, Ahn, SungMin, Aparicio, Samuel, Arnould, Laurent, Aure, M R, Bhosle, Shriram G, Birney, Ewan, Borg, Ake, Boyault, Sandrine, Brinkman, Arie B, Brock, Jane E, Broeks, Annegien, BorresenDale, AnneLise, Caldas, Carlos, Chin, SuetFeung, Davies, Helen, Desmedt, Christine, Dirix, Luc, Dronov, Serge, Ehinger, Anna, Eyfjord, Jorunn E, Fatima, Aquila, Foekens, John A, Futreal, P Andrew, Garred, Oystein, Giri, Dilip D, Glodzik, Dominik, Grabau, Dorthe, Hilmarsdottir, Holmfridur, Hooijer, Gerrit K, Jacquemier, Jocelyne, Jang, Se Jin, Jonasson, Jon G, Jonkers, Jos, Kim, HyungYong, King, Tari A, Knappskog, Stian, Kong, Gu, Krishnamurthy, Savitri, Lakhani, Sunil R, Langerod, Anita, Larsimont, Denis, Lee, Hee Jin, Lee, JeongYeon, Lee, Ming Ta Michael, Lingjaerde, Ole Christian, MacGrogan, Gaetan, Martens, John W M, OMeara, Sarah, Pauporte, Iris, Pinder, Sarah, Pivot, Xavier, Provenzano, Elena, Purdie, Colin A, Ramakrishna, Manasa, Ramakrishnan, Kamna, ReisFilho, Jorge, Richardson, Andrea L, Ringner, Markus, Rodriguez, Javier Bartolome, RodriguezGonzalez, F German, Romieu, Gilles, Salgado, Roberto, Sauer, Torill, Shepherd, Rebecca, Sieuwerts, Anieta M, Simpson, Peter T, Smid, Marcel, Sotiriou, Christos, Span, Paul N, Stefansson, Olafur Andri, Stenhouse, Alasdair, Stunnenberg, Henk G, Sweep, Fred, Tan, Benita Kiat Tee, Thomas, Gilles, Thompson, Alastair M, Tommasi, Stefania, Treilleux, Isabelle, Tutt, Andrew, Ueno, Naoto T, Van Laere, Steven, Van den Eynden, Gert G, Vermeulen, Peter, Viari, Alain, VincentSalomon, Anne, Wong, Bernice H, Yates, Lucy, Zou, Xueqing, van Deurzen, Carolien H M, van de Vijver, Marc J, vant Veer, Laura, Ammerpohl, Ole, Aukema, Sietse, Bergmann, Anke K, Bernhart, Stephan H, Borkhardt, Arndt, Borst, Christoph, Burkhardt, Birgit, Claviez, Alexander, Goebler, Maria Elisabeth, Haake, Andrea, Haas, Siegfried, Hansmann, Martin, Hoell, Jessica, I, Hummel, Michael, Karsch, Dennis, Klapper, Wolfram, Kneba, Michael, Kreuz, Markus, Kube, Dieter, Kueppers, Ralf, Lenze, Dido, Loeffler, Markus, Lopez, Cristina, MantovaniLoeffler, Luisa, Moeller, Peter, Ott, German, Radlwimmer, Bernhard, Richter, Julia, Rohde, Marius, Rosenstiel, Philip C, Rosenwald, Andreas, Schilhabel, Markus B, Schreiber, Stefan, Stadler, Peter F, Staib, Peter, Stilgenbauer, Stephan, Sungalee, Stephanie, Szczepanowski, Monika, Toprak, Umut H, Truemper, Lorenz H P, Wagener, Rabea, Zenz, Thorsten, Hovestadt, Volker, von Kalle, Christof, Kool, Marcel, Korshunov, Andrey, Landgraf, Pablo, Lehrach, Hans, Northcott, Paul A, Pfister, Stefan M, Reifenberger, Guido, Warnatz, HansJoerg, Wolf, Stephan, Yaspo, MarieLaure, Assenov, Yassen, Gerhauser, Clarissa, Minner, Sarah, Schlomm, Thorsten, Simon, Ronald, Sauter, Guido, Sueltmann, Holger, Biswas, Nidhan K, Maitra, Arindam, Majumder, Partha P, Sarin, Rajiv, Barbi, Stefano, Bonizzato, Giada, Cantu, Cinzia, Dei Tos, Angelo P, Fassan, Matteo, Grimaldi, Sonia, Luchini, Claudio, Malleo, Giuseppe, Marchegiani, Giovanni, Milella, Michele, Paiella, Salvatore, Pea, Antonio, Pederzoli, Paolo, Ruzzenente, Andrea, Salvia, Roberto, Sperandio, Nicola, Arai, Yasuhito, Hama, Natsuko, Hiraoka, Nobuyoshi, Hosoda, Fumie, Nakamura, Hiromi, Ojima, Hidenori, Okusaka, Takuji, Totoki, Yasushi, Urushidate, Tomoko, Fukayama, Masashi, Ishikawa, Shumpei, Katai, Hitoshi, Katoh, Hiroto, Komura, Daisuke, Rokutan, Hirofumi, SaitoAdachi, Mihoko, Suzuki, Akihiro, Taniguchi, Hirokazu, Tatsuno, Kenji, Ushiku, Tetsuo, Yachida, Shinichi, Yamamoto, Shogo, Aikata, Hiroshi, Arihiro, Koji, Ariizumi, Shunichi, Chayama, Kazuaki, Furuta, Mayuko, Gotoh, Kunihito, Hayami, Shinya, Hirano, Satoshi, Kawakami, Yoshiiku, Maejima, Kazuhiro, Nakamura, Toru, Nakano, Kaoru, Ohdan, Hideki, SasakiOku, Aya, Tanaka, Hiroko, Ueno, Masaki, Yamamoto, Masakazu, Yamaue, Hiroki, Choo, Su Pin, Cutcutache, Ioana, Khuntikeo, Narong, Ong, Choon Kiat, Pairojkul, Chawalit, Popescu, Irinel, Ahn, Keun Soo, Aymerich, Marta, LopezGuillermo, Armando, LopezOtin, Carlos, Puente, Xose S, Campo, Elias, Amary, Fernanda, Baumhoer, Daniel, Behjati, Sam, Bjerkehagen, Bodil, Futreal, P A, Myklebost, Ola, Pillay, Nischalan, Tarpey, Patrick, Tirabosco, Roberto, Zaikova, Olga, Flanagan, Adrienne M, Boultwood, Jacqueline, Bowen, David T, Cazzola, Mario, Green, Anthony R, HellstromLindberg, Eva, Malcovati, Luca, Nangalia, Jyoti, Papaemmanuil, Elli, Vyas, Paresh, Ang, Yeng, Barr, Hugh, Beardsmore, Duncan, Eldridge, Matthew, Gossage, James, Grehan, Nicola, Hanna, George B, Hayes, Stephen J, Hupp, Ted R, Khoo, David, Lagergren, Jesper, Lovat, Laurence B, MacRae, Shona, ODonovan, Maria, ONeill, J Robert, Parsons, Simon L, Preston, Shaun R, Puig, Sonia, Roques, Tom, Sanders, Grant, Sothi, Sharmila, Tavare, Simon, Tucker, Olga, Turkington, Richard, Underwood, Timothy J, Welch, Ian, Fitzgerald, Rebecca C, Berney, Daniel M, De Bono, Johann S, Cahill, Declan, Camacho, Niedzica, Dennis, Nening M, Dudderidge, Tim, Edwards, Sandra E, Fisher, Cyril, Foster, Christopher S, Ghori, Mohammed, Gill, Pelvender, Gnanapragasam, Vincent J, Gundem, Gunes, Hamdy, Freddie C, Hawkins, Steve, Hazell, Steven, Howat, William, Isaacs, William B, Karaszi, Katalin, Kay, Jonathan D, Khoo, Vincent, KoteJarai, Zsofia, Kremeyer, Barbara, Kumar, Pardeep, Lambert, Adam, Leongamornlert, Daniel A, Livni, Naomi, Lu, YongJie, Luxton, Hayley J, Marsden, Luke, Massie, Charlie E, Matthews, Lucy, Mayer, Erik, McDermott, Ultan, Merson, Sue, Neal, David E, Ng, Anthony, Nicol, David, Ogden, Christopher, Rowe, Edward W, Shah, Nimish C, Thomas, Sarah, Thompson, Alan, Verrill, Clare, Visakorpi, Tapio, Warren, Anne Y, Whitaker, Hayley C, Zhang, Hongwei, van As, Nicholas, Eeles, Rosalind A, Abeshouse, Adam, Agrawal, Nishant, Akbani, Rehan, Al Ahmadie, Hikmat, Albert, Monique, Aldape, Kenneth, Ally, Adrian, Appelbaum, Elizabeth L, Armenia, Joshua, Asa, Sylvia, Auman, J Todd, Balasundaram, Miruna, Balu, Saianand, BarnholtzSloan, Jill, Bathe, Oliver F, Baylin, Stephen B, Benz, Christopher, Berchuck, Andrew, Berrios, Mario, Bigner, Darell, Birrer, Michael, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S, Bosenberg, Marcus, Bowlby, Reanne, Boyd, Jeffrey, Broaddus, Russell R, Brock, Malcolm, Brooks, Denise, Bullman, Susan, CaesarJohnson, Samantha J, Carey, Thomas E, Carlsen, Rebecca, Cerfolio, Robert, Chandan, Vishal S, Chen, HsiaoWei, Cherniack, Andrew D, Chien, Jeremy, Cho, Juok, Chuah, Eric, Cibulskis, Carrie, Cope, Leslie, Cordes, Matthew G, Curley, Erin, Czerniak, Bogdan, Danilova, Ludmila, Davis, Ian J, Defreitas, Timothy, Demchok, John A, Dhalla, Noreen, Dhir, Rajiv, Doddapaneni, HarshaVardhan, ElNaggar, Adel, Felau, Ina, Ferguson, Martin L, Finocchiaro, Gaetano, Fong, Kwun M, Frazer, Scott, Friedman, William, Fronick, Catrina C, Fulton, Lucinda A, Gabriel, Stacey B, Gao, Jianjiong, Gehlenborg, Nils, Gershenwald, Jeffrey E, Ghossein, Ronald, Giama, Nasra H, Gibbs, Richard A, Gomez, Carmen, Govindan, Ramaswamy, Hayes, D Neil, Hegde, Apurva M, Heiman, David, I, Heins, Zachary, Hepperla, Austin J, Holbrook, Andrea, Holt, Robert A, Hoyle, Alan P, Hruban, Ralph H, Hu, Jianhong, Huang, Mei, Huntsman, David, Huse, Jason, Donahue, Christine A Iacobuzio, Ittmann, Michael, Jayaseelan, Joy C, Jefferys, Stuart R, Jones, Corbin D, Jones, Steven J M, Juhl, Hartmut, Kang, Koo Jeong, Karlan, Beth, Kasaian, Katayoon, Kebebew, Electron, Kim, Hark Kyun, Korchina, Viktoriya, Kundra, Ritika, Lai, Phillip H, Lander, Eric, Le, Xuan, Lee, Darlene, Levine, Douglas A, Lewis, Lora, Ley, Tim, Li, Haiyan Irene, Lin, Pei, Linehan, W M, Liu, Fei Fei, Lu, Yiling, Lype, Lisa, Ma, Yussanne, Maglinte, Dennis T, Mardis, Elaine R, Marks, Jeffrey, Marra, Marco A, Matthew, Thomas J, Mayo, Michael, McCune, Karen, Meier, Samuel R, Meng, Shaowu, Mieczkowski, Piotr A, Mikkelsen, Tom, Miller, Christopher A, Mills, Gordon B, Moore, Richard A, Morrison, Carl, Mose, Lisle E, Moser, Catherine D, Mungall, Andrew J, Mungall, Karen, Mutch, David, Muzny, Donna M, Myers, Jerome, Newton, Yulia, Noble, Michael S, ODonnell, Peter, ONeill, Brian Patrick, Ochoa, Angelica, Park, JoongWon, Parker, Joel S, Pass, Harvey, Pastore, Alessandro, Pennell, Nathan A, Perou, Charles M, Petrelli, Nicholas, Potapova, Olga, Rader, Janet S, Ramalingam, Suresh, Rathmell, W Kimryn, Reuter, Victor, Reynolds, Sheila M, Ringel, Matthew, Roach, Jeffrey, Roberts, Lewis R, Robertson, A Gordon, Sadeghi, Sara, Saller, Charles, SanchezVega, Francisco, Schadendorf, Dirk, Schein, Jacqueline E, Schmidt, Heather K, Schultz, Nikolaus, Seethala, Raja, Senbabaoglu, Yasin, Shelton, Troy, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Shriver, Craig, Signoretti, Sabina, Simons, Janae, V, Singer, Samuel, Sipahimalani, Payal, Skelly, Tara J, McCune, Karen Smith, Socci, Nicholas D, Soloway, Matthew G, Sood, Anil K, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Thiessen, Nina, Thompson, R Houston, Thorne, Leigh B, Tsao, Ming, Umbricht, Christopher, Van Den Berg, David J, Van Meir, Erwin G, Veluvolu, Umadevi, Voet, Douglas, Wang, Linghua, Weinberger, Paul, Weisenberger, Daniel J, Wigle, Dennis, Wilkerson, Matthew D, Wilson, Richard K, Winterhoff, Boris, Wiznerowicz, Maciej, Wong, Tina, Wong, Winghing, Xi, Liu, Yau, Christina, Zhang, Hailei, Zhang, Hongxin, Zhang, Jiashan. Pan-cancer analysis of whole genomes. NATURE[J]. 2020, 578(7793):&nbsp82-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000529097800007.[29] Yuan, Yuan, Ju, Young Seok, Kim, Youngwook, Li, Jun, Wang, Yumeng, Yoon, Christopher J, Yang, Yang, Martincorena, Inigo, Creighton, Chad J, Weinstein, John N, Xu, Yanxun, Han, Leng, Kim, HyungLae, Nakagawa, Hidewaki, Park, Keunchil, Campbell, Peter J, Liang, Han, PCAWG Consortium. Comprehensive molecular characterization of mitochondrial genomes in human cancers. NATURE GENETICS[J]. 2020, 52(3):&nbsp342-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000511282900005.[30] CarlevaroFita, Joana, Lanzos, Andres, Feuerbach, Lars, Hong, Chen, MasPonte, David, Pedersen, Jakob Skou, Johnson, Rory, Abascal, Federico, Amin, Samirkumar B, Bader, Gary D, Barenboim, Jonathan, Beroukhim, Rameen, Bertl, Johanna, Boroevich, Keith A, Brunak, Soren, Campbell, Peter J, CarlevaroFita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Chen, Ken, Choi, Jung Kyoon, DeuPons, Jordi, Dhingra, Priyanka, Diamanti, Klev, Feuerbach, Lars, Fink, J Lynn, Fonseca, Nuno A, Frigola, Joan, GambacortiPasserini, Carlo, Garsed, Dale W, Gerstein, Mark, Getz, Gad, GonzalezPerez, Abel, Guo, Qianyun, Gut, Ivo G, Haan, David, Hamilton, Mark P, Haradhvala, Nicholas J, Harmanci, Arif O, Helmy, Mohamed, Herrmann, Carl, Hess, Julian M, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Hornshoj, Henrik, Isaev, Keren, Izarzugaza, Jose M G, Johnson, Todd A, Juul, Malene, Juul, Randi Istrup, Kahles, Andre, Kahraman, Abdullah, Kellis, Manolis, Khurana, Ekta, Kim, Jaegil, Kim, Jong K, Kim, Youngwook, Komorowski, Jan, Korbel, Jan O, Kumar, Sushant, Lanzos, Andres, Larsson, Erik, Lawrence, Michael S, Lee, Donghoon, Lehmann, KjongVan, Li, Shantao, Li, Xiaotong, Lin, Ziao, Liu, Eric Minwei, Lochovsky, Lucas, Lou, Shaoke, Madsen, Tobias, Marchal, Kathleen, Martincorena, Inigo, MartinezFundichely, Alexander, Maruvka, Yosef E, McGillivray, Patrick D, Meyerson, William, Muinos, Ferran, Mularoni, Loris, Nakagawa, Hidewaki, Nielsen, Morten Muhlig, Paczkowska, Marta, Park, Keunchil, Park, Kiejung, Pedersen, Jakob Skou, Pich, Oriol, Pons, Tirso, PulidoTamayo, Sergio, Raphael, Benjamin J, Reimand, Juri, ReyesSalazar, Iker, Reyna, Matthew A, Rheinbay, Esther, Rubin, Mark A, RubioPerez, Carlota, Sabarinathan, Radhakrishnan, Sahinalp, S Cenk, Saksena, Gordon, Salichos, Leonidas, Sander, Chris, Schumacher, Steven E, Shackleton, Mark, Shapira, Ofer, Shen, Ciyue, Shrestha, Raunak, Shuai, Shimin, Sidiropoulos, Nikos, Sieverling, Lina, SinnottArmstrong, Nasa, Stein, Lincoln D, Stuart, Joshua M, Tamborero, David, Tiao, Grace, Tsunoda, Tatsuhiko, Umer, Husen M, UuskulaReimand, Liis, Valencia, Alfonso, Vazquez, Miguel, Verbeke, Lieven P C, Wadelius, Claes, Wadi, Lina, Wang, Jiayin, Warrell, Jonathan, Waszak, Sebastian M, Weischenfeldt, Joachim, Wheeler, David A, Wu, Guanming, Yu, Jun, Zhang, Jing, Zhang, Xuanping, Zhang, Yan, Zhao, Zhongming, Zou, Lihua, von Mering, Christian, PCAWG Drivers Functional, PCAWG Consortium. Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1):&nbsphttp://dx.doi.org/10.1038/s42003-019-0741-7.[31] Lina Sieverling, Chen Hong, Sandra D Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M Braun, Isidro CortsCiriano, Ruibin Xi, Rolf Kabbe, Peter J Park, Roland Eils, Matthias Schlesner, PCAWGStructural Variation Working Group, Benedikt Brors, Karsten Rippe, David T W Jones, Lars Feuerbach, PCAWG Consortium. Genomic footprints of activated telomere maintenance mechanisms in cancer. Nature Communications[J]. 2020, 11(1):&nbsp1-13, https://doaj.org/article/f5ba2ff084914f529104ae4627a4c3f7.[32] 何志鹏, 李瑞琳, 牛北方. 高可用弹性宏基因组学计算平台. 计算机科学[J]. 2020, 48(1):&nbsp326-332, http://lib.cqvip.com/Qikan/Article/Detail?id=7103774857.[33] Matthew A Reyna, David Haan, Marta Paczkowska, Lieven P C Verbeke, Miguel Vazquez, Abdullah Kahraman, Sergio PulidoTamayo, Jonathan Barenboim, Lina Wadi, Priyanka Dhingra, Raunak Shrestha, Gad Getz, Michael S Lawrence, Jakob Skou Pedersen, Mark A Rubin, David A Wheeler, Sren Brunak, Jose M G Izarzugaza, Ekta Khurana, Kathleen Marchal, Christian von Mering, S Cenk Sahinalp, Alfonso Valencia, PCAWG Drivers and Functional Interpretation Working Group, Jri Reimand, Joshua M Stuart, Benjamin J Raphael, PCAWG Consortium. Pathway and network analysis of more than 2500 whole cancer genomes. Nature Communications[J]. 2020, 11(1):&nbsp1-17, https://doaj.org/article/d9995364c8fb4afc89d4bb8a8bc2379d.[34] Gerstung, Moritz, Jolly, Clemency, Leshchiner, Ignaty, Dentro, Stefan C, Gonzalez, Santiago, Rosebrock, Daniel, Mitchell, Thomas J, Rubanova, Yulia, Anur, Pavana, Yu, Kaixian, Tarabichi, Maxime, Deshwar, Amit, Wintersinger, Jeff, Kleinheinz, Kortine, VazquezGarcia, Ignacio, Haase, Kerstin, Jerman, Lara, Sengupta, Subhajit, Macintyre, Geoff, Malikic, Salem, Donmez, Nilgun, Livitz, Dimitri G, Cmero, Marek, Demeulemeester, Jonas, Schumacher, Steven, Fan, Yu, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Boutros, Paul C, Bowtell, David D, Zhu, Hongtu, Getz, Gad, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S Cenk, Ji, Yuan, Peifer, Martin, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Wang, Wenyi, Morris, Quaid D, Spellman, Paul T, Wedge, David C, Van Loo, Peter, Deshwar, Amit G, Adams, David J, Campbell, Peter J, Cao, Shaolong, Christie, Elizabeth L, Cun, Yupeng, Dawson, Kevin J, Drews, Ruben M, Eils, Roland, Fittall, Matthew, Garsed, Dale W, Ha, Gavin, LeeSix, Henry, Martincorena, Inigo, Oesper, Layla, Peto, Myron, Raphael, Benjamin J, Salcedo, Adriana, Shi, Ruian, Shin, Seung Jun, Spiro, Oliver, Stein, Lincoln D, Vembu, Shankar, Wheeler, David A, Yang, TsunPo, PCAWG Evolution Heterogeneity Work, PCAWG Consortium. The evolutionary history of 2,658 cancers. NATURE[J]. 2020, 578(7793):&nbsp122-+, http://dx.doi.org/10.1038/s41586-019-1907-7.[35] Akdemir, Kadir C, Le, Victoria T, Chandran, Sahaana, Li, Yilong, Verhaak, Roel G, Beroukhim, Rameen, Campbell, Peter J, Chin, Lynda, Dixon, Jesse R, Futreal, P Andrew, Alvarez, Eva G, BaezOrtega, Adrian, Beroukhim, Rameen, Boutros, Paul C, Bowtell, David D L, Brors, Benedikt, Burns, Kathleen H, Chan, Kin, Chen, Ken, CortesCiriano, Isidro, DuesoBarroso, Ana, Dunford, Andrew J, Edwards, Paul A, Estivill, Xavier, Etemadmoghadam, Dariush, Feuerbach, Lars, Fink, J Lynn, FrenkelMorgenstern, Milana, Garsed, Dale W, Gerstein, Mark, Gordenin, Dmitry A, Haan, David, Haber, James E, Hess, Julian M, Hutter, Barbara, Imielinski, Marcin, Jones, David T W, Ju, Young Seok, Kazanov, Marat D, Klimczak, Leszek J, Koh, Youngil, Korbel, Jan O, Kumar, Kiran, Lee, Eunjung Alice, Lee, Jake JuneKoo, Lynch, Andy G, Macintyre, Geoff, Markowetz, Florian, Martincorena, Inigo, MartinezFundichely, Alexander, Meyerson, Matthew, Miyano, Satoru, Nakagawa, Hidewaki, Navarro, Fabio C P, Ossowski, Stephan, Park, Peter J, Pearson, John V, Puiggros, Montserrat, Rippe, Karsten, Roberts, Nicola D, Roberts, Steven A, RodriguezMartin, Bernardo, Schumacher, Steven E, Scully, Ralph, Shackleton, Mark, Sidiropoulos, Nikos, Sieverling, Lina, Stewart, Chip, Torrents, David, Tubio, Jose M C, Villasante, Izar, Waddell, Nicola, Wala, Jeremiah A, Weischenfeldt, Joachim, Yang, Lixing, Yao, Xiaotong, Yoon, SungSoo, Zamora, Jorge, Zhang, ChengZhong, PCAWG Struct Variation Working Grp, PCAWG Consortium. Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. NATURE GENETICS[J]. 2020, 52(3):&nbsp294-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000511282900003.[36] Vinayak Bhandari, Constance H Li, Robert G Bristow, Paul C Boutros, PCAWG Consortium. Divergent mutational processes distinguish hypoxic and normoxic tumours. Nature Communications[J]. 2020, 11(1):&nbsp1-10, https://doaj.org/article/4c1bcf031d81481c82255bf73212374c.[37] Alexandrov, Ludmil B, Kim, Jaegil, Haradhvala, Nicholas J, Huang, Mi Ni, Ng, Alvin Wei Tian, Wu, Yang, Boot, Arnoud, Covington, Kyle R, Gordenin, Dmitry A, Bergstrom, Erik N, Islam, S M Ashiqul, LopezBigas, Nuria, Klimczak, Leszek J, McPherson, John R, Morganella, Sandro, Sabarinathan, Radhakrishnan, Wheeler, David A, Mustonen, Ville, Getz, Gad, Rozen, Steven G, Stratton, Michael R, PCAWG Mutational Signatures Workin, PCAWG Consortium. The repertoire of mutational signatures in human cancer. NATURE[J]. 2020, 578(7793):&nbsp94-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000529097800008.[38] Dai, Chuangchuang, Luan, Haijing, Yu, Qingbing, He, Xiaoyu, Wang, Yunhao, Shuai, Bincheng, Guo, Xiaobing, Lu, Zhonghua, Niu, Beifang. Change-Encryption: Encryption Using Spatiotemporal Information as a Function Model. 2020 7TH IEEE INTERNATIONAL CONFERENCE ON CYBER SECURITY AND CLOUD COMPUTING (CSCLOUD 2020)/2020 6TH IEEE INTERNATIONAL CONFERENCE ON EDGE COMPUTING AND SCALABLE CLOUD (EDGECOM 2020)null. 2020, 281-287, http://dx.doi.org/10.1109/CSCloud-EdgeCom49738.2020.00056.[39] Shimin Shuai, PCAWG Drivers and Functional Interpretation Working Group, Steven Gallinger, Lincoln Stein, PCAWG Consortium. Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nature Communications[J]. 2020, 11(1):&nbsp1-12, https://doaj.org/article/142b65513ccf441182a79c2cf78b29df.[40] RodriguezMartin, Bernardo, Alvarez, Eva G, BaezOrtega, Adrian, Zamora, Jorge, Supek, Fran, Demeulemeester, Jonas, Santamarina, Martin, Ju, Young Seok, Temes, Javier, GarciaSouto, Daniel, Detering, Harald, Li, Yilong, RodriguezCastro, Jorge, DuesoBarroso, Ana, Bruzos, Alicia L, Dentro, Stefan C, Blanco, Miguel G, Contino, Gianmarco, Ardeljan, Daniel, Tojo, Marta, Roberts, Nicola D, Zumalave, Sonia, Edwards, Paul A W, Weischenfeldt, Joachim, Puiggros, Montserrat, Chong, Zechen, Chen, Ken, Lee, Eunjung Alice, Wala, Jeremiah A, Raine, Keiran, Butler, Adam, Waszak, Sebastian M, Navarro, Fabio C P, Schumacher, Steven E, Monlong, Jean, Maura, Francesco, Bolli, Niccolo, Bourque, Guillaume, Gerstein, Mark, Park, Peter J, Wedge, David C, Beroukhim, Rameen, Torrents, David, Korbel, Jan O, Martincorena, Inigo, Fitzgerald, Rebecca C, Van Loo, Peter, Kazazian, Haig H, Burns, Kathleen H, Campbell, Peter J, Tubio, Jose M C, Akdemir, Kadir C, Boutros, Paul C, Bowtell, David D L, Brors, Benedikt, Chan, Kin, CortesCiriano, Isidro, Dunford, Andrew J, Edwards, Paul A, Estivill, Xavier, Etemadmoghadam, Dariush, Feuerbach, Lars, Fink, J Lynn, FrenkelMorgenstern, Milana, Garsed, Dale W, Gordenin, Dmitry A, Haan, David, Haber, James E, Hess, Julian M, Hutter, Barbara, Imielinski, Marcin, Jones, David T W, Kazanov, Marat D, Klimczak, Leszek J, Koh, Youngil, Kumar, Kiran, Lee, Jake JuneKoo, Lynch, Andy G, Macintyre, Geoff, Markowetz, Florian, MartinezFundichely, Alexander, Meyerson, Matthew, Miyano, Satoru, Nakagawa, Hidewaki, Ossowski, Stephan, Pearson, John, V, Rippe, Karsten, Roberts, Steven A, Scully, Ralph, Shackleton, Mark, Sidiropoulos, Nikos, Sieverling, Lina, Stewart, Chip, Villasante, Izar, Waddell, Nicola, Yang, Lixing, Yao, Xiaotong, Yoon, SungSoo, Zhang, ChengZhong, PCAWG Struct Variation Working Grp, PCAWG Consortium. Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. NATURE GENETICS[J]. 2020, 52(3):&nbsp306-+, http://dx.doi.org/10.1038/s41588-019-0562-0.[41] Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schrder, PCAWG Evolution and Heterogeneity Working Group, Niall M Corcoran, Tony Papenfuss, Christopher M Hovens, Florian Markowetz, Geoff Macintyre, PCAWG Consortium. Inferring structural variant cancer cell fraction. Nature Communications[J]. 2020, 11(1):&nbsp1-15, http://dx.doi.org/10.1038/s41467-020-14351-8.[42] Rheinbay, Esther, Nielsen, Morten Muhlig, Abascal, Federico, Wala, Jeremiah A, Shapira, Ofer, Tiao, Grace, Hornshoj, Henrik, Hess, Julian M, Juul, Randi Istrup, Lin, Ziao, Feuerbach, Lars, Sabarinathan, Radhakrishnan, Madsen, Tobias, Kim, Jaegil, Mularoni, Loris, Shuai, Shimin, Lanzos, Andres, Herrmann, Carl, Maruvka, Yosef E, Shen, Ciyue, Amin, Samirkumar B, Bandopadhayay, Pratiti, Bertl, Johanna, Boroevich, Keith A, Busanovich, John, CarlevaroFita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Craft, David, Dhingra, Priyanka, Diamanti, Klev, Fonseca, Nuno A, GonzalezPerez, Abel, Guo, Qianyun, Hamilton, Mark P, Haradhvala, Nicholas J, Hong, Chen, Isaev, Keren, Johnson, Todd A, Juul, Malene, Kahles, Andre, Kahraman, Abdullah, Kim, Youngwook, Komorowski, Jan, Kumar, Kiran, Kumar, Sushant, Lee, Donghoon, Lehmann, KjongVan, Li, Yilong, Liu, Eric Minwei, Lochovsky, Lucas, Park, Keunchil, Pich, Oriol, Roberts, Nicola D, Saksena, Gordon, Schumacher, Steven E, Sidiropoulos, Nikos, Sieverling, Lina, SinnottArmstrong, Nasa, Stewart, Chip, Tamborero, David, Tubio, Jose M C, Umer, Husen M, UuskulaReimand, Liis, Wadelius, Claes, Wadi, Lina, Yao, Xiaotong, Zhang, ChengZhong, Zhang, Jing, Haber, James E, Hobolth, Asger, Imielinski, Marcin, Kellis, Manolis, Lawrence, Michael S, von Mering, Christian, Nakagawa, Hidewaki, Raphael, Benjamin J, Rubin, Mark A, Sander, Chris, Stein, Lincoln D, Stuart, Joshua M, Tsunoda, Tatsuhiko, Wheeler, David A, Johnson, Rory, Reimand, Juri, Gerstein, Mark, Khurana, Ekta, Campbell, Peter J, LopezBigas, Nuria, Weischenfeldt, Joachim, Beroukhim, Rameen, Martincorena, Inigo, Pedersen, Jakob Skou, Getz, Gad, Bader, Gary D, Barenboim, Jonathan, Brunak, Soren, Chen, Ken, Choi, Jung Kyoon, DeuPons, Jordi, Fink, J Lynn, Frigola, Joan, GambacortiPasserini, Carlo, Garsed, Dale W, Gut, Ivo G, Haan, David, Harmanci, Arif O, Helmy, Mohamed, Hodzic, Ermin, Izarzugaza, Jose M G, Kim, Jong K, Korbel, Jan O, Larsson, Erik, Li, Shantao, Li, Xiaotong, Lou, Shaoke, Marchal, Kathleen, MartinezFundichely, Alexander, McGillivray, Patrick D, Meyerson, William, Muinos, Ferran, Paczkowska, Marta, Park, Kiejung, Pons, Tirso, PulidoTamayo, Sergio, ReyesSalazar, Iker, Reyna, Matthew A, RubioPerez, Carlota, Sahinalp, S Cenk, Salichos, Leonidas, Shackleton, Mark, Shrestha, Raunak, Valencia, Alfonso, Vazquez, Miguel, Verbeke, Lieven P C, Wang, Jiayin, Warrell, Jonathan, Waszak, Sebastian M, Wu, Guanming, Yu, Jun, Zhang, Xuanping, Zhang, Yan, Zhao, Zhongming, Zou, Lihua, Akdemir, Kadir C, Alvarez, Eva G, BaezOrtega, Adrian, Boutros, Paul C, Bowtell, David D L, Brors, Benedikt, Burns, Kathleen H, Chan, Kin, CortesCiriano, Isidro, DuesoBarroso, Ana, Dunford, Andrew J, Edwards, Paul A, Estivill, Xavier, Etemadmoghadam, Dariush, FrenkelMorgenstern, Milana, Gordenin, Dmitry A, Hutter, Barbara, Jones, David T W, Ju, Young Seok, Kazanov, Marat D, Klimczak, Leszek J, Koh, Youngil, Lee, Eunjung Alice, Lee, Jake JuneKoo, Lynch, Andy G, Macintyre, Geoff, Markowetz, Florian, Meyerson, Matthew, Miyano, Satoru, Navarro, Fabio C P, Ossowski, Stephan, Park, Peter J, Pearson, John, V, Puiggros, Montserrat, Rippe, Karsten, Roberts, Steven A, RodriguezMartin, Bernardo, Scully, Ralph, Torrents, David, Villasante, Izar, Waddell, Nicola, Yang, Lixing, Yoon, SungSoo, Zamora, Jorge, PCAWG Drivers Functional Interpr, PCAWG Struct Variation Working Grp, PCAWG Consortium. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. NATURE[J]. 2020, 578(7793):&nbsp102-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000529097800009.[43] Matthew H Bailey, William U Meyerson, Lewis Jonathan Dursi, LiangBo Wang, Guanlan Dong, WenWei Liang, Amila Weerasinghe, Shantao Li, Yize Li, Sean Kelso, MC3 Working Group, PCAWG novel somatic mutation calling methods working group, Gordon Saksena, Kyle Ellrott, Michael C Wendl, David A Wheeler, Gad Getz, Jared T Simpson, Mark B Gerstein, Li Ding, PCAWG Consortium. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. NATURE COMMUNICATIONS[J]. 2020, 11(1):&nbsphttps://www.webofscience.com/wos/woscc/full-record/WOS:000607169300001.[44] Yiqun Zhang, Fengju Chen, Nuno A Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brazma, PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Chad J Creighton, PCAWG Consortium. High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. NATURE COMMUNICATIONS[J]. 2020, 11(1):&nbsphttp://dx.doi.org/10.1038/s41467-019-13885-w.[45] Li, Yilong, Roberts, Nicola D, Wala, Jeremiah A, Shapira, Ofer, Schumacher, Steven E, Kumar, Kiran, Khurana, Ekta, Waszak, Sebastian, Korbel, Jan O, Haber, James E, Imielinski, Marcin, Weischenfeldt, Joachim, Beroukhim, Rameen, Campbell, Peter J, Akdemir, Kadir C, Alvarez, Eva G, BaezOrtega, Adrian, Boutros, Paul C, Bowtell, David D L, Brors, Benedikt, Burns, Kathleen H, Chan, Kin, Chen, Ken, CortesCiriano, Isidro, DuesoBarroso, Ana, Dunford, Andrew J, Edwards, Paul A, Estivill, Xavier, Etemadmoghadam, Dariush, Feuerbach, Lars, Fink, J Lynn, FrenkelMorgenstern, Milana, Garsed, Dale W, Gerstein, Mark, Gordenin, Dmitry A, Haan, David, Hess, Julian M, Hutter, Barbara, Jones, David T W, Ju, Young Seok, Kazanov, Marat D, Klimczak, Leszek J, Koh, Youngil, Lee, Eunjung Alice, Lee, Jake JuneKoo, Lynch, Andy G, Macintyre, Geoff, Markowetz, Florian, Martincorena, Inigo, MartinezFundichely, Alexander, Meyerson, Matthew, Miyano, Satoru, Nakagawa, Hidewaki, Navarro, Fabio C P, Ossowski, Stephan, Park, Peter J, Pearson, John, V, Puiggros, Montserrat, Rippe, Karsten, Roberts, Steven A, RodriguezMartin, Bernardo, Scully, Ralph, Shackleton, Mark, Sidiropoulos, Nikos, Sieverling, Lina, Stewart, Chip, Torrents, David, Tubio, Jose M C, Villasante, Izar, Waddell, Nicola, Yang, Lixing, Yao, Xiaotong, Yoon, SungSoo, Zamora, Jorge, Zhang, ChengZhong, PCAWG Struct Variation Working Grp, PCAWG Consortium. Patterns of somatic structural variation in human cancer genomes. NATURE[J]. 2020, 578(7793):&nbsp112-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000529097800010.[46] Wei Jiao, Gurnit Atwal, Paz Polak, Rosa Karlic, Edwin Cuppen, PCAWG Tumor Subtypes and Clinical Translation Working Group, Alexandra Danyi, Jeroen de Ridder, Carla van Herpen, Martijn P Lolkema, Neeltje Steeghs, Gad Getz, Quaid Morris, Lincoln D Stein, PCAWG Consortium. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nature Communications[J]. 2020, 11(1):&nbsp1-12, https://doaj.org/article/1eb66053b1d54801a9b93093526fbf22.[47] 祝海栋, 李瑞琳, 何小雨, 赵丹, 韩鑫胤, 牛北方. 六倍体小麦基因组注释流程构建与优化. 计算机系统应用[J]. 2019, 28(8):&nbsp222-228, http://lib.cqvip.com/Qikan/Article/Detail?id=7002704287.[48] 赵丹, 尚秋明, 韩鑫胤, 李瑞琳, 何小雨, 祝海栋, 牛北方. 单肿瘤组织微卫星不稳定探测方法. 计算机系统应用[J]. 2019, 28(9):&nbsp50-57, http://lib.cqvip.com/Qikan/Article/Detail?id=7100112794.[49] 赵得雄, 尚秋明, 栾海晶, 代闯闯, 李瑞琳, 何小雨, 韩鑫胤, 祝海栋, 何志鹏, 牛北方, 迟学斌, 陆忠华. 以青海为代表的全国新生儿出生缺陷研究综述. 科研信息化技术与应用[J]. 2019, 10(2):&nbsp78-88, http://lib.cqvip.com/Qikan/Article/Detail?id=7100270703.[50] 张裕, 牛北方. 一种轻量级分布式作业管理系统的设计与实现. 科研信息化技术与应用[J]. 2019, 10(1):&nbsp31-37, http://lib.cqvip.com/Qikan/Article/Detail?id=7100193452.[51] Yin, Zekun, Xu, Xiaoming, Fan, Kaichao, Li, Ruilin, Li, Weizhong, Liu, Weiguo, Niu, Beifang. DGCF: A Distributed Greedy Clustering Framework for Large-scale Genomic Sequences. 2019 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)null. 2019, 2272-2279, [52] Chen, Shanyu, He, Zhipeng, Han, Xinyin, He, Xiaoyu, Li, Ruilin, Zhu, Haidong, Zhao, Dan, Dai, Chuangchuang, Zhang, Yu, Lu, Zhonghua, Chi, Xuebin, Niu, Beifang. How Big Data and High-performance Computing Drive Brain Science. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2019, 17(4):&nbsp381-392, http://lib.cqvip.com/Qikan/Article/Detail?id=7101029393.[53] Li, Ruilin, He, Xiaoyu, Dai, Chuangchuang, Zhu, Haidong, Lang, Xianyu, Chen, Wei, Li, Xiaodong, Zhao, Dan, Zhang, Yu, Han, Xinyin, Niu, Tie, Zhao, Yi, Cao, Rongqiang, He, Rong, Lu, Zhonghua, Chi, Xuebin, Li, Weizhong, Niu, Beifang. Gclust: A Parallel Clustering Tool for Microbial Genomic Data. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2019, 17(5):&nbsp496-502, http://lib.cqvip.com/Qikan/Article/Detail?id=00002HUHLL7G7JP167DO4JP1MHR.[54] Junlan Zhu, Zhongxian Tian, Yang Li, Xiaohui Hua, Dongyun Zhang, Jingxia Li, Honglei Jin, Jiheng Xu, Wei Chen, Beifang Niu, XueRu Wu, Sergio Comincini, Haishan Huang, Chuanshu Huang. ATG7 Promotes Bladder Cancer Invasion via Autophagy‐Mediated Increased ARHGDIB mRNA Stability. Advanced Science[J]. 2019, 6(8):&nbspn/a-n/a, https://onlinelibrary.wiley.com/doi/10.1002/advs.201801927.[55] 李瑞琳, 尚秋明, 韩鑫胤, 张裕, 祝海栋, LI Weizhong, 牛北方. 基于宏基因组长片段的基因预测算法基准. 计算机应用[J]. 2019, 39(A01):&nbsp143-149, http://lib.cqvip.com/Qikan/Article/Detail?id=7002573523.[56] Li, Shuo, Lu, Zhonghua, Sun, Yongze, Deng, Sungen, Niu, Beifang. Distributed Parameter Optimization Scheduling Strategy and System Design Based on Mesos. 2019 IEEE 5TH INTL CONFERENCE ON BIG DATA SECURITY ON CLOUD (BIGDATASECURITY) / IEEE INTL CONFERENCE ON HIGH PERFORMANCE AND SMART COMPUTING (HPSC) / IEEE INTL CONFERENCE ON INTELLIGENT DATA AND SECURITY (IDS)null. 2019, 218-224, http://dx.doi.org/10.1109/BigDataSecurity-HPSC-IDS.2019.00050.[57] Cao, Yanan, Zhou, Weiwei, Li, Lin, Wang, Jiaqian, Gao, Zhibo, Jiang, Yiran, Jiang, Xiuli, Shan, Aijing, Bailey, Matthew H, Huang, KuanLin, Sun, Sam Q, McLellan, Michael D, Niu, Beifang, Wang, Weiqing, Ding, Li, Ning, Guang. Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types. CELL RESEARCH[J]. 2018, 28(5):&nbsp601-604, http://lib.cqvip.com/Qikan/Article/Detail?id=675657278.[58] 陈玮, 赵丹, 李晓东, 何小雨, 李瑞琳, 牛北方. 肿瘤微卫星不稳定检测方法综述. 计算机系统应用[J]. 2018, 27(10):&nbsp39-45, http://lib.cqvip.com/Qikan/Article/Detail?id=676541338.[59] Sun, Liping, Fan, Fengyan, Li, Ruilin, Niu, Beifang, Zhu, Liguo, Yu, Shuai, Wang, Shuying, Li, Cuiying, Wang, Deqing. Different Erythrocyte MicroRNA Profiles in Low- and High-Altitude Individuals. FRONTIERS IN PHYSIOLOGY[J]. 2018, 9: http://www.corc.org.cn/handle/1471x/2374227.[60] Zhou, Wei, Li, Ruilin, Yuan, Shuo, Liu, ChangChun, Yao, Shaowen, Luo, Jing, Niu, Beifang. MetaSpark: a spark-based distributed processing tool to recruit metagenomic reads to reference genomes. BIOINFORMATICS[J]. 2017, 33(7):&nbsp1090-1092, http://www.corc.org.cn/handle/1471x/2374221.[61] 李晓东, 何小雨, 陈玮, 李瑞琳, 赵丹, 祝海栋, 张裕, 代闯闯, 陆忠华, 迟学斌, 牛北方, 郎显宇. 四种肿瘤体细胞单核苷酸突变检测方法的比较. 科研信息化技术与应用[J]. 2017, 8(6):&nbsp77-87, http://lib.cqvip.com/Qikan/Article/Detail?id=675348932.[62] Mashl, R Jay, Scott, Adam D, Huang, Kuanlin, Wyczalkowski, Matthew A, Yoon, Christopher J, Niu, Beifang, DeNardo, Erin, Yellapantula, Venkata D, Handsaker, Robert E, Chen, Ken, Koboldt, Daniel C, Ye, Kai, Fenyo, David, Raphael, Benjamin J, Wendl, Michael C, Ding, Li. GenomeVIP: a cloud platform for genomic variant discovery and interpretation. GENOME RESEARCH[J]. 2017, 27(8):&nbsp1450-1459, http://dx.doi.org/10.1101/gr.211656.116.[63] Kuanlin Huang, Shunqiang Li, Philipp Mertins, Song Cao, Harsha P Gunawardena, Kelly V Ruggles, D R Mani, Karl R Clauser, Maki Tanioka, Jerry Usary, Shyam M Kavuri, Ling Xie, Christopher Yoon, Jana W Qiao, John Wrobel, Matthew A Wyczalkowski, Petra ErdmannGilmore, Jacqueline E Snider, Jeremy Hoog, Purba Singh, Beifang Niu, Zhanfang Guo, Sam Qiancheng Sun, Souzan Sanati, Emily Kawaler, Xuya Wang, Adam Scott, Kai Ye, Michael D McLellan, Michael C Wendl, Anna Malovannaya, Jason M Held, Michael A Gillette, David Feny, Christopher R Kinsinger, Mehdi Mesri, Henry Rodriguez, Sherri R Davies, Charles M Perou, Cynthia Ma, R Reid Townsend, Xian Chen, Steven A Carr, Matthew J Ellis, Li Ding. Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. NATURE COMMUNICATIONS[J]. 2017, 8(1):&nbsphttps://doaj.org/article/1c26a6238dc4471f89a26c07ab836e61.[64] Ye, Kai, Wang, Jiayin, Jayasinghe, Reyka, Lameijer, EricWubbo, McMichael, Joshua F, Ning, Jie, McLellan, Michael D, Xie, Mingchao, Cao, Song, Yellapantula, Venkata, Huang, Kuanlin, Scott, Adam, Foltz, Steven, Niu, Beifang, Johnson, Kimberly J, Moed, Matthijs, Slagboom, P Eline, Chen, Feng, Wendl, Michael C, Ding, Li. Systematic discovery of complex insertions and deletions in human cancers. NATURE MEDICINE[J]. 2016, 22(1):&nbsp97-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000367590700021.[65] Niu, Beifang, Scott, Adam D, Sengupta, Sohini, Bailey, Matthew H, Batra, Prag, Ning, Jie, Wyczalkowski, Matthew A, Liang, WenWei, Zhang, Qunyuan, McLellan, Michael D, Sun, Sam Q, Tripathi, Piyush, Lou, Carolyn, Ye, Kai, Mashl, R Jay, Wallis, John, Wendl, Michael C, Chen, Feng, Ding, Li. Protein-structure-guided discovery of functional mutations across 19 cancer types. NATURE GENETICS[J]. 2016, 48(8):&nbsp827-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000380755100005.[66] Cao, Song, Wendl, Michael C, Wyczalkowski, Matthew A, Wylie, Kristine, Ye, Kai, Jayasinghe, Reyka, Xie, Mingchao, Wu, Song, Niu, Beifang, Grubb, Robert, III, Johnson, Kimberly J, Gay, Hiram, Chen, Ken, Rader, Janet S, Dipersio, John F, Chen, Feng, Ding, Li. Divergent viral presentation among human tumors and adjacent normal tissues. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000378550300001.[67] Lu, Charles, Xie, Mingchao, Wendl, Michael C, Wang, Jiayin, McLellan, Michael D, Leiserson, Mark D M, Huang, Kuanlin, Wyczalkowski, Matthew A, Jayasinghe, Reyka, Banerjee, Tapahsama, Ning, Jie, Tripathi, Piyush, Zhang, Qunyuan, Niu, Beifang, Ye, Kai, Schmidt, Heather K, Fulton, Robert S, McMichael, Joshua F, Batra, Prag, Kandoth, Cyriac, Bharadwaj, Maheetha, Koboldt, Daniel C, Miller, Christopher A, Kanchi, Krishna L, Eldred, James M, Larson, David E, Welch, John S, You, Ming, Ozenberger, Bradley A, Govindan, Ramaswamy, Walter, Matthew J, Ellis, Matthew J, Mardis, Elaine R, Graubert, Timothy A, Dipersio, John F, Ley, Timothy J, Wilson, Richard K, Goodfellow, Paul J, Raphael, Benjamin J, Chen, Feng, Johnson, Kimberly J, Parvin, Jeffrey D, Ding, Li. Patterns and functional implications of rare germline variants across 12 cancer types. NATURE COMMUNICATIONS[J]. 2015, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000367569400006.[68] Leiserson, Mark D M, Vandin, Fabio, Wu, HsinTa, Dobson, Jason R, Eldridge, Jonathan V, Thomas, Jacob L, Papoutsaki, Alexandra, Kim, Younhun, Niu, Beifang, McLellan, Michael, Lawrence, Michael S, GonzalezPerez, Abel, Tamborero, David, Cheng, Yuwei, Ryslik, Gregory A, LopezBigas, Nuria, Getz, Gad, Ding, Li, Raphael, Benjamin J. Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. NATURE GENETICS[J]. 2015, 47(2):&nbsp106-114, https://www.webofscience.com/wos/woscc/full-record/WOS:000348694700005.[69] Sengupta, Sohini, Ye, Kai, Scott, Adam D, Niu, Beifang, Bailey, Matthew H, McLellan, Michael D, Wendl, Michael C, Wyczalkowski, Matthew A, Ding, Li. Sequence and structure-guided approach to identify functional mutations in G-protein coupled receptors. CANCER RESEARCHnull. 2015, 75: [70] Niu, Beifang, Ye, Kai, Zhang, Qunyuan, Lu, Charles, Xie, Mingchao, McLellan, Michael D, Wendl, Michael C, Ding, Li. MSIsensor: microsatellite instability detection using paired tumor-normal sequence data. BIOINFORMATICS[J]. 2014, 30(7):&nbsp1015-1016, https://www.webofscience.com/wos/woscc/full-record/WOS:000334078300021.[71] Hoadley, Katherine A, Yau, Christina, Wolf, Denise M, Cherniack, Andrew D, Tamborero, David, Ng, Sam, Leiserson, Max D M, Niu, Beifang, McLellan, Michael D, Uzunangelov, Vladislav, Zhang, Jiashan, Kandoth, Cyriac, Akbani, Rehan, Shen, Hui, Omberg, Larsson, Chu, Andy, Margolin, Adam A, vant Veer, Laura J, LopezBigas, Nuria, Laird, Peter W, Raphael, Benjamin J, Ding, Li, Robertson, A Gordon, Byers, Lauren A, Mills, Gordon B, Weinstein, John N, Van Waes, Carter, Chen, Zhong, Collisson, Eric A, Canc Genome Atlas Res Network, Benz, Christopher C, Perou, Charles M, Stuart, Joshua M. Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin. CELL[J]. 2014, 158(4):&nbsp929-944, http://dx.doi.org/10.1016/j.cell.2014.06.049.[72] Bass, Adam J, Thorsson, Vesteinn, Shmulevich, Ilya, Reynolds, Sheila M, Miller, Michael, Bernard, Brady, Hinoue, Toshinori, Laird, Peter W, Curtis, Christina, Shen, Hui, Weisenberger, Daniel J, Schultz, Nikolaus, Shen, Ronglai, Weinhold, Nils, Keiser, David P, Bowlby, Reanne, Sipahimalani, Payal, Cherniack, Andrew D, Getz, Gad, Liu, Yingchun, Noble, Michael S, Pedamallu, Chandra, Sougnez, Carrie, TaylorWeiner, Amaro, Akbani, Rehan, Lee, JuSeog, Liu, Wenbin, Mills, Gordon B, Yang, Da, Zhang, Wei, Pantazi, Angeliki, Parfenov, Michael, Gulley, Margaret, Piazuelo, M Blanca, Schneider, Barbara G, Kim, Jihun, Boussioutas, Alex, Sheth, Margi, Demchok, John A, Rabkin, Charles S, Willis, Joseph E, Ng, Sam, Garman, Katherine, Beer, David G, Pennathur, Arjun, Raphael, Benjamin J, Wu, HsinTa, Odze, Robert, Kim, Hark K, Bowen, Jay, Leraas, Kristen M, Lichtenberg, Tara M, Weaver, Lichtenberg, McLellan, Michael, Wiznerowicz, Maciej, Sakai, Ryo, Getz, Gad, Sougnez, Carrie, Lawrence, Michael S, Cibulskis, Kristian, Lichtenstein, Lee, Fisher, Sheila, Gabriel, Stacey B, Lander, Eric S, Ding, Li, Niu, Beifang, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Bowlby, Reanne, Brooks, Denise, Butterfield, Yaron S N, Carlsen, Rebecca, Chu, Andy, Chu, Justin, Chuah, Eric, Chun, HyeJung E, Clarke, Amanda, Dhalla, Noreen, Guin, Ranabir, Holt, Robert A, Jones, Steven J M, Kasaian, Katayoon, Lee, Darlene, Li, Haiyan A, Lim, Emilia, Ma, Yussanne, Marra, Marco A, Mayo, Michael, Moore, Richard A, Mungall, Andrew J, Mungall, Karen L, Nip, Ka Ming, Robertson, A Gordon, Schein, Jacqueline E, Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Beroukhim, Rameen, Carter, Scott L, Cherniack, Andrew D, Cho, Juok, Cibulskis, Kristian, DiCara, Daniel, Frazer, Scott, Fisher, Sheila, Gabriel, Stacey B, Gehlenborg, Nils, Heiman, David I, Jung, Joonil, Kim, Jaegil, Lander, Eric S, Lawrence, Michael S, Lichtenstein, Lee, Lin, Pei, Meyerson, Matthew, Ojesina, Akinyemi I, Pedamallu, Chandra Sekhar, Saksena, Gordon, Schumacher, Steven E, Sougnez, Carrie, Stojanov, Petar, Tabak, Barbara, TaylorWeiner, Amaro, Voet, Doug, Rosenberg, Mara, Zack, Travis I, Zhang, Hailei, Zou, Lihua, Protopopov, Alexei, Santoso, Netty, Parfenov, Michael, Lee, Semin, Zhang, Jianhua, Mahadeshwar, Harshad S, Tang, Jiabin, Ren, Xiaojia, Seth, Sahil, Yang, Lixing, Xu, Andrew W, Song, Xingzhi, Pantazi, Angeliki, Xi, Ruibin, Bristow, Christopher A, Hadjipanayis, Angela, Seidman, Jonathan, Chin, Lynda, Park, Peter J, Kucherlapati, Raju, Akbani, Rehan, Ling, Shiyun, Liu, Wenbin, Rao, Arvind, Weinstein, John N, Kim, SangBae, Lee, JuSeog, Lu, Yiling, Mills, Gordon, Hinoue, Toshinori, Weisenberger, Daniel J, Bootwalla, Moiz S, Lai, Phillip H, Shen, Hui, Triche, Timothy, Jr, Van Den Berg, David J, Baylin, Stephen B, Herman, James G, Getz, Gad, Chin, Lynda, Liu, Yingchun, Murray, Bradley A, Noble, Michael S, Askoy, B Arman, Ciriello, Giovanni, Dresdner, Gideon, Gao, Jianjiong, Gross, Benjamin, Jacobsen, Anders, Lee, William, Ramirez, Ricardo, Sander, Chris, Schultz, Nikolaus, Senbabaoglu, Yasin, Sinha, Rileen, Sumer, S Onur, Sun, Yichao, Weinhold, Nils, Thorsson, Vesteinn, Bernard, Brady, Iype, Lisa, Kramer, Roger W, Kreisberg, Richard, Miller, Michael, Reynolds, Sheila M, Rovira, Hector, Tasman, Natalie, Shmulevich, Ilya, Ng, Sam, Haussler, David, Stuart, Josh M, Akbani, Rehan, Ling, Shiyun, Liu, Wenbin, Rao, Arvind, Weinstein, John N, Verhaak, Roeland G W, Mills, Gordon B, Leiserson, Mark D M, Raphael, Benjamin J, Wu, HsinTa, Taylor, Barry S, Black, Aaron D, Bowen, Jay, Carney, Julie Ann, GastierFoster, Julie M, Helsel, Carmen, Leraas, Kristen M, Lichtenberg, Tara M, McAllister, Cynthia, Ramirez, Nilsa C, Tabler, Teresa R, Wise, Lisa, Zmuda, Erik, Penny, Robert, Crain, Daniel, Gardner, Johanna, Lau, Kevin, Curely, Erin, Mallery, David, Morris, Scott, Paulauskis, Joseph, Shelton, Troy, Shelton, Candace, Sherman, Mark, Benz, Christopher, Lee, JaeHyuk, Fedosenko, Konstantin, Manikhas, Georgy, Voronina, Olga, Belyaev, Dmitry, Dolzhansky, Oleg, Rathmell, W Kimryn, Brzezinski, Jakub, Ibbs, Matthew, Korski, Konstanty, Kycler, Witold, Lazniak, Radoslaw, Leporowska, Ewa, Mackiewicz, Andrzej, Murawa, Dawid, Murawa, Pawel, Spychala, Arkadiusz, Suchorska, Wiktoria M, Tatka, Honorata, Teresiak, Marek, Wiznerowicz, Maciej, AbdelMisih, Raafat, Bennett, Joseph, Brown, Jennifer, Iacocca, Mary, Rabeno, Brenda, Kwon, SunYoung, Penny, Robert, Gardner, Johanna, Kemkes, Ariane, Mallery, David, Morris, Scott, Shelton, Troy, Shelton, Candace, Curley, Erin, Alexopoulou, Iakovina, Engel, Jay, Bartlett, John, Albert, Monique, Park, DoYoun, Dhir, Rajiv, Luketich, James, Landreneau, Rodney, Janjigian, Yelena Y, Kelsen, David P, Cho, Eunjung, Ladanyi, Marc, Tang, Laura, McCall, Shannon J, Park, Young S, Cheong, JaeHo, Ajani, Jaffer, Camargo, M Constanza, Alonso, Shelley, Ayala, Brenda, Jensen, Mark A, Pihl, Todd, Raman, Rohini, Walton, Jessica, Wan, Yunhu, Demchok, John A, Eley, Greg, Shaw, Kenna R Mills, Sheth, Margi, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Zenklusen, Jean Claude, Davidsen, Tanja, Hutter, Carolyn M, Sofia, Heidi J, Burton, Robert, Chudamani, Sudha, Liu, Jia, Canc Genome Atlas Res Network. Comprehensive molecular characterization of gastric adenocarcinoma. NATURE[J]. 2014, 513(7517):&nbsp202-209, https://www.webofscience.com/wos/woscc/full-record/WOS:000341362800044.[73] Kandoth, Cyriac, McLellan, Michael D, Miller, Christopher A, Lu, Charles, Dees, Nathan, Ye, Kai, Niu, Beifang, Wendl, Michael C, Wilson, Richard K, Ding, Li. Mutational and clonal analyses across TCGA cancer types using the MuSiC suite of tools.. CANCER RESEARCHnull. 2013, 73(8):&nbsphttps://www.webofscience.com/wos/woscc/full-record/WOS:000331220601168.[74] Zhu, Zhengwei, Niu, Beifang, Chen, Jing, Wu, Sitao, Sun, Shulei, Li, Weizhong. MGAviewer: a desktop visualization tool for analysis of metagenomics alignment data. BIOINFORMATICS[J]. 2013, 29(1):&nbsp122-123, https://www.webofscience.com/wos/woscc/full-record/WOS:000312654600019.[75] Walter, M J, Shen, D, Shao, J, Ding, L, White, B S, Kandoth, C, Miller, C A, Niu, B, McLellan, M D, Dees, N D, Fulton, R, Elliot, K, Heath, S, Grillot, M, Westervelt, P, Link, D C, DiPersio, J F, Mardis, E, Ley, T J, Wilson, R K, Graubert, T A. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. LEUKEMIA[J]. 2013, 27(6):&nbsp1275-1282, https://www.webofscience.com/wos/woscc/full-record/WOS:000319917500008.[76] Chen, Ken, Navin, Nicholas E, Wang, Yong, Schmidt, Heather K, Wallis, John W, Niu, Beifang, Fan, Xian, Zhao, Hao, McLellan, Michael D, Hoadley, Katherine A, Mardis, Elaine R, Ley, Timothy J, Perou, Charles M, Wilson, Richard K, Ding, Li. BreakTrans: uncovering the genomic architecture of gene fusions. GENOME BIOLOGY[J]. 2013, 14(8):&nbspR87-R87, https://www.webofscience.com/wos/woscc/full-record/WOS:000328195400005.[77] Kandoth, Cyriac, McLellan, Michael D, Vandin, Fabio, Ye, Kai, Niu, Beifang, Lu, Charles, Xie, Mingchao, Zhang, Qunyuan, McMichael, Joshua F, Wyczalkowski, Matthew A, Leiserson, Mark D M, Miller, Christopher A, Welch, John S, Walter, Matthew J, Wendl, Michael C, Ley, Timothy J, Wilson, Richard K, Raphael, Benjamin J, Ding, Li. Mutational landscape and significance across 12 major cancer types. NATURE[J]. 2013, 502(7471):&nbsp333-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000325706300045.[78] Fu, Limin, Niu, Beifang, Zhu, Zhengwei, Wu, Sitao, Li, Weizhong. CD-HIT: accelerated for clustering the next-generation sequencing data. BIOINFORMATICS[J]. 2012, 28(23):&nbsp3150-3152, https://www.webofscience.com/wos/woscc/full-record/WOS:000311902700023.[79] Li, Weizhong, Fu, Limin, Niu, Beifang, Wu, Sitao, Wooley, John. Ultrafast clustering algorithms for metagenomic sequence analysis. BRIEFINGS IN BIOINFORMATICS[J]. 2012, 13(6):&nbsp656-668, http://dx.doi.org/10.1093/bib/bbs035.[80] Wu, Sitao, Zhu, Zhengwei, Fu, Liming, Niu, Beifang, Li, Weizhong. WebMGA: a customizable web server for fast metagenomic sequence analysis. BMC GENOMICS[J]. 2011, 12(1):&nbsp444-444, http://dx.doi.org/10.1186/1471-2164-12-444.[81] Niu, Beifang, Zhu, Zhengwei, Fu, Limin, Wu, Sitao, Li, Weizhong. FR-HIT, a very fast program to recruit metagenomic reads to homologous reference genomes. BIOINFORMATICS[J]. 2011, 27(12):&nbsp1704-1705, https://www.webofscience.com/wos/woscc/full-record/WOS:000291261300020.[82] Niu, Beifang, Fu, Limin, Sun, Shulei, Li, Weizhong. Artificial and natural duplicates in pyrosequencing reads of metagenomic data. BMC BIOINFORMATICS[J]. 2010, 11(1):&nbsp187-187, http://dx.doi.org/10.1186/1471-2105-11-187.[83] Huang, Ying, Niu, Beifang, Gao, Ying, Fu, Limin, Li, Weizhong. CD-HIT Suite: a web server for clustering and comparing biological sequences. BIOINFORMATICS[J]. 2010, 26(5):&nbsp680-682, http://dx.doi.org/10.1093/bioinformatics/btq003.[84] 郭新, 牛北方. 基于大规模序列比对软件的并行优化方案. 计算机工程[J]. 2009, 35(3):&nbsp91-93, http://lib.cqvip.com/Qikan/Article/Detail?id=29403332.[85] Niu, BeiFang, Lang, XianYu, Lu, ZhongHua, Chi, XueBin. Parallel Algorithm Research on Several Important Open Problems in Bioinformatics. INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES[J]. 2009, 1(3):&nbsp187-195, http://www.corc.org.cn/handle/1471x/2374120.[86] 牛北方, 张西广, 刘涛, 郎显宇, 陆忠华, 迟学斌. 基于新测序技术的比对与组装算法. 计算机工程[J]. 2009, 35(20):&nbsp4-6, http://lib.cqvip.com/Qikan/Article/Detail?id=31855898.[87] 牛北方, 郎显宇, 陆忠华, 迟学斌. mRNA可变剪接问题的并行化研究. 计算机应用研究[J]. 2008, 25(3):&nbsp705-708, http://lib.cqvip.com/Qikan/Article/Detail?id=26713723.[88] Niu, B F, Lang, X Y, Lu, Z H, Chi, X B. ScBioGrid: a commodity supercomputing environment supporting bioinformatics research. INTERNATIONAL JOURNAL OF COMPUTER MATHEMATICS[J]. 2007, 84(2):&nbsp177-182, http://www.corc.org.cn/handle/1471x/2374099.[89] 朱骥, 杨华, 牛北方, 郎显宇, 陆忠华, 迟学斌. Motif识别算法简介及软件性能研究. 计算机应用研究[J]. 2006, 23(10):&nbsp66-69, [90] 郎显宇, 牛北方, 沈斌, 陆忠华, 迟学斌. 分子空间结构比较方法优化与点部署的并行实现. 计算机研究与发展[J]. 2005, 42(6):&nbsp1047-1052, http://lib.cqvip.com/Qikan/Article/Detail?id=15707300.
发表著作
（1） FR-HIT Overview, SpringerReference, 2014-06, 第 1 作者（2） Clustering-based HMP Sequence Comparison, SpringerReference, 2014-06, 第 1 作者（3） Fast program for clustering and comparing large sets of protein or nucleotide sequences, SpringerReference, 2014-06, 第 2 作者
科研活动
科研项目
（ 1 ）&nbsp泛癌体细胞突变热点分析算法研究, 主持, 国家级, 2018-05--2021-12（ 2 ）&nbsp国家高性能计算环境中虚拟数据空间运行支撑技术, 主持, 国家级, 2018-05--2021-04（ 3 ）&nbsp生态环境损害鉴定评估业务化技术研究, 主持, 国家级, 2016-07--2020-12（ 4 ）&nbsp组学数据挖掘的高性能开源软件系统, 主持, 部委级, 2016-01--2018-12（ 5 ）&nbsp大尺度基因组重构与注释的高性能软件系统, 主持, 部委级, 2017-01--2020-12（ 6 ）&nbsp个性化药物—基于疾病分子分型的惠普新药研发, 参与, 部委级, 2015-10--2018-12（ 7 ）&nbsp基于高通量测序技术的新生儿出生缺陷筛查新技术研究与示范, 主持, 省级, 2016-01--2018-12（ 8 ）&nbsp宫颈癌组学数据深度挖掘分析, 主持, 研究所（学校）, 2017-05--2019-12（ 9 ）&nbsp面向生命健康大数据分析的新计算架构与人工智能方法, 主持, 部委级, 2020-01--2024-12
参与会议
（1）MSI及TMB高表达人群数据挖掘算法 第二十二届“全国临床肿瘤学大会暨2019年CSCO学术年” 2018-09-18（2）Pan-cancer Analysis of Genomics Sequencing Big Data International Workshop on CO-DESIGN 2016-10-27（3）Protein-structure-guided discovery of functional mutations across 19 cancer types International Symposium on Clinical and Translational Medicine 2016-09-22（4）Mutational Landscape and Significance Across Pan-Cancer 第四届“数学、计算机与生命科学交叉研究”青年学者论坛 2016-05-21
合作情况
项目协作单位
The McDonnell Genome Institute, School of Medicine, Washington University in St. Louis, Missouri, US.San Diego Supercomputer Center(SDSC), University of California, San Diego, California, US.The J. Craig Venter Institute (JCVI), La Jolla, San Diego, California, US. The General Hospital of the People's Liberation Army (PLAGH), Beijing, China.
指导学生
已指导学生李瑞琳 博士研究生 081202-计算机软件与理论 赵丹 硕士研究生 085211-计算机技术 张裕 硕士研究生 081202-计算机软件与理论 祝海栋 硕士研究生 081203-计算机应用技术 何小雨 博士研究生 081202-计算机软件与理论 陈玮 硕士研究生 081202-计算机软件与理论 陈珊羽 硕士研究生 085211-计算机技术 何志鹏 硕士研究生 085211-计算机技术 张舒莹 硕士研究生 085211-计算机技术 袁丹阳 硕士研究生 081202-计算机软件与理论 余果 硕士研究生 025100-金融 刘月琳 硕士研究生 025100-金融 现指导学生郝卉群 博士研究生 081202-计算机软件与理论 代闯闯 博士研究生 081202-计算机软件与理论 程世宇 博士研究生 081202-计算机软件与理论 冀德韬 硕士研究生 081202-计算机软件与理论 胡季芳 硕士研究生 081202-计算机软件与理论 栾海晶 博士研究生 081202-计算机软件与理论
2013 中国科学院大学，网络信息中心.